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Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

Author

Listed:
  • Melih Acar

    (University of Texas Southwestern Medical Center)

  • Kiranmai S. Kocherlakota

    (Howard Hughes Medical Institute, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Malea M. Murphy

    (University of Texas Southwestern Medical Center)

  • James G. Peyer

    (University of Texas Southwestern Medical Center)

  • Hideyuki Oguro

    (University of Texas Southwestern Medical Center)

  • Christopher N. Inra

    (University of Texas Southwestern Medical Center)

  • Christabel Jaiyeola

    (University of Texas Southwestern Medical Center)

  • Zhiyu Zhao

    (University of Texas Southwestern Medical Center)

  • Katherine Luby-Phelps

    (University of Texas Southwestern Medical Center)

  • Sean J. Morrison

    (Howard Hughes Medical Institute, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

Abstract

α-catulin is identified as a marker to locate functional haematopoiteic stem cells in deep imaging experiments of bone marrow, showing that α-catulin–GFP+c-kit+ cells commonly reside in perisinusoidal niches throughout the bone marrow.

Suggested Citation

  • Melih Acar & Kiranmai S. Kocherlakota & Malea M. Murphy & James G. Peyer & Hideyuki Oguro & Christopher N. Inra & Christabel Jaiyeola & Zhiyu Zhao & Katherine Luby-Phelps & Sean J. Morrison, 2015. "Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal," Nature, Nature, vol. 526(7571), pages 126-130, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7571:d:10.1038_nature15250
    DOI: 10.1038/nature15250
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    Cited by:

    1. Young-Woong Kim & Greta Zara & HyunJun Kang & Sergio Branciamore & Denis O’Meally & Yuxin Feng & Chia-Yi Kuan & Yingjun Luo & Michael S. Nelson & Alex B. Brummer & Russell Rockne & Zhen Bouman Chen & , 2022. "Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Raymond K. H. Yip & Joel S. Rimes & Bianca D. Capaldo & François Vaillant & Kellie A. Mouchemore & Bhupinder Pal & Yunshun Chen & Elliot Surgenor & Andrew J. Murphy & Robin L. Anderson & Gordon K. Smy, 2021. "Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    3. Brandon Hadland & Barbara Varnum-Finney & Stacey Dozono & Tessa Dignum & Cynthia Nourigat-McKay & Adam M. Heck & Takashi Ishida & Dana L. Jackson & Tomer Itkin & Jason M. Butler & Shahin Rafii & Cole , 2022. "Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Adrienne Anginot & Julie Nguyen & Zeina Abou Nader & Vincent Rondeau & Amélie Bonaud & Maria Kalogeraki & Antoine Boutin & Julia P. Lemos & Valeria Bisio & Joyce Koenen & Lea Hanna Doumit Sakr & Amand, 2023. "WHIM Syndrome-linked CXCR4 mutations drive osteoporosis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    5. Yang Liu & Qi Chen & Hyun-Woo Jeong & Bong Ihn Koh & Emma C. Watson & Cong Xu & Martin Stehling & Bin Zhou & Ralf H. Adams, 2022. "A specialized bone marrow microenvironment for fetal haematopoiesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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