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Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

Author

Listed:
  • Stefani Spranger

    (The University of Chicago)

  • Riyue Bao

    (Center for Research Informatics, The University of Chicago)

  • Thomas F. Gajewski

    (The University of Chicago
    The University of Chicago)

Abstract

Only a subset of patients with melanoma responds to new immunotherapeutic therapies; here, β-catenin signalling is identified as an important pathway that confers resistance to this type of approach, with implications for future treatment strategies.

Suggested Citation

  • Stefani Spranger & Riyue Bao & Thomas F. Gajewski, 2015. "Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity," Nature, Nature, vol. 523(7559), pages 231-235, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7559:d:10.1038_nature14404
    DOI: 10.1038/nature14404
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    Cited by:

    1. Jodi M. Carter & Saranya Chumsri & Douglas A. Hinerfeld & Yaohua Ma & Xue Wang & David Zahrieh & David W. Hillman & Kathleen S. Tenner & Jennifer M. Kachergus & Heather Ann Brauer & Sarah E. Warren & , 2023. "Distinct spatial immune microlandscapes are independently associated with outcomes in triple-negative breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Yafei Jiang & Jinzeng Wang & Mengxiong Sun & Dongqing Zuo & Hongsheng Wang & Jiakang Shen & Wenyan Jiang & Haoran Mu & Xiaojun Ma & Fei Yin & Jun Lin & Chongren Wang & Shuting Yu & Lu Jiang & Gang Lv , 2022. "Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Aditi Sahu & Kivanc Kose & Lukas Kraehenbuehl & Candice Byers & Aliya Holland & Teguru Tembo & Anthony Santella & Anabel Alfonso & Madison Li & Miguel Cordova & Melissa Gill & Christi Fox & Salvador G, 2022. "In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Zhen Lu & Jinyun Chen & Pengfei Yu & Matthew J. Atherton & Jun Gui & Vivek S. Tomar & Justin D. Middleton & Neil T. Sullivan & Sunil Singhal & Subin S. George & Ashley G. Woolfork & Aalim M. Weljie & , 2022. "Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. Junmeng Zhu & Yaohua Ke & Qin Liu & Ju Yang & Fangcen Liu & Ruihan Xu & Hang Zhou & Aoxing Chen & Jie Xiao & Fanyan Meng & Lixia Yu & Rutian Li & Jia Wei & Baorui Liu, 2022. "Engineered Lactococcus lactis secreting Flt3L and OX40 ligand for in situ vaccination-based cancer immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    6. Su Yin Lim & Elena Shklovskaya & Jenny H. Lee & Bernadette Pedersen & Ashleigh Stewart & Zizhen Ming & Mal Irvine & Brindha Shivalingam & Robyn P. M. Saw & Alexander M. Menzies & Matteo S. Carlino & R, 2023. "The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    7. Shravan Leonard-Murali & Chetana Bhaskarla & Ghanshyam S. Yadav & Sudeep K. Maurya & Chenna R. Galiveti & Joshua A. Tobin & Rachel J. Kann & Eishan Ashwat & Patrick S. Murphy & Anish B. Chakka & Visha, 2024. "Uveal melanoma immunogenomics predict immunotherapy resistance and susceptibility," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    8. Yunxing Shi & Zongfeng Wu & Shaoru Liu & Dinglan Zuo & Yi Niu & Yuxiong Qiu & Liang Qiao & Wei He & Jiliang Qiu & Yunfei Yuan & Guocan Wang & Binkui Li, 2024. "Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    9. Andrew Patterson & Noam Auslander, 2022. "Mutated processes predict immune checkpoint inhibitor therapy benefit in metastatic melanoma," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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