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REV7 counteracts DNA double-strand break resection and affects PARP inhibition

Author

Listed:
  • Guotai Xu

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • J. Ross Chapman

    (The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK)

  • Inger Brandsma

    (Erasmus, University Medical Center, 3000 CA Rotterdam, The Netherlands)

  • Jingsong Yuan

    (University of Texas MD Anderson Cancer Center)

  • Martin Mistrik

    (Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic)

  • Peter Bouwman

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Jirina Bartkova

    (Danish Cancer Society Research Center, 2100 Copenhagen, Denmark)

  • Ewa Gogola

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Daniël Warmerdam

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Marco Barazas

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Janneke E. Jaspers

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Kenji Watanabe

    (Danish Cancer Society Research Center, 2100 Copenhagen, Denmark)

  • Mark Pieterse

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Ariena Kersbergen

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Wendy Sol

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Patrick H. N. Celie

    (Protein Facility, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Philip C. Schouten

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Bram van den Broek

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Ahmed Salman

    (The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK)

  • Marja Nieuwland

    (Deep Sequencing Core Facility, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Iris de Rink

    (Deep Sequencing Core Facility, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Jorma de Ronde

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Kees Jalink

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Simon J. Boulton

    (DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms, Hertfordshire EN6 3LD, UK)

  • Junjie Chen

    (University of Texas MD Anderson Cancer Center)

  • Dik C. van Gent

    (Erasmus, University Medical Center, 3000 CA Rotterdam, The Netherlands)

  • Jiri Bartek

    (Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic
    Danish Cancer Society Research Center, 2100 Copenhagen, Denmark)

  • Jos Jonkers

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Piet Borst

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands)

  • Sven Rottenberg

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
    Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Laengassstrasse 122, 3012 Bern, Switzerland)

Abstract

Loss of REV7 is shown to regulate end resection of double-stranded DNA breaks in BRCA1-deficient cells, leading to PARP inhibitor resistance and restoration of homologous recombination; REV7 dictates pathway choice in BRCA1-deficient cells and during immunoglobulin class switching.

Suggested Citation

  • Guotai Xu & J. Ross Chapman & Inger Brandsma & Jingsong Yuan & Martin Mistrik & Peter Bouwman & Jirina Bartkova & Ewa Gogola & Daniël Warmerdam & Marco Barazas & Janneke E. Jaspers & Kenji Watanabe & , 2015. "REV7 counteracts DNA double-strand break resection and affects PARP inhibition," Nature, Nature, vol. 521(7553), pages 541-544, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7553:d:10.1038_nature14328
    DOI: 10.1038/nature14328
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    Citations

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    Cited by:

    1. Takuya Tsujino & Tomoaki Takai & Kunihiko Hinohara & Fu Gui & Takeshi Tsutsumi & Xiao Bai & Chenkui Miao & Chao Feng & Bin Gui & Zsofia Sztupinszki & Antoine Simoneau & Ning Xie & Ladan Fazli & Xuesen, 2023. "CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Sameer Bikram Shah & Youhang Li & Shibo Li & Qing Hu & Tong Wu & Yanmeng Shi & Tran Nguyen & Isaac Ive & Linda Shi & Hailong Wang & Xiaohua Wu, 2024. "53BP1 deficiency leads to hyperrecombination using break-induced replication (BIR)," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Yajie Sun & Jeffrey Patterson-Fortin & Sen Han & Zhe Li & Zuzanna Nowicka & Yuna Hirohashi & Susan Kilgas & Jae Kyo Yi & Alexander Spektor & Wojciech Fendler & Panagiotis A. Konstantinopoulos & Dipanj, 2024. "53BP1 loss elicits cGAS-STING-dependent antitumor immunity in ovarian and pancreatic cancer," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Zeliha Yalçin & Shiu Yeung Lam & Marieke H. Peuscher & Jaco Torre & Sha Zhu & Prasanna V. Iyengar & Daniel Salas-Lloret & Inge Krijger & Nathalie Moatti & Ruben Lugt & Mattia Falcone & Aurora Cerutti , 2024. "UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    5. Inés Paniagua & Zainab Tayeh & Mattia Falcone & Santiago Hernández Pérez & Aurora Cerutti & Jacqueline J. L. Jacobs, 2022. "MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Estelle Vincendeau & Wenming Wei & Xuefei Zhang & Cyril Planchais & Wei Yu & Hélène Lenden-Hasse & Thomas Cokelaer & Juliana Pipoli da Fonseca & Hugo Mouquet & David J. Adams & Frederick W. Alt & Step, 2022. "SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    7. Sumin Feng & Sai Ma & Kejiao Li & Shengxian Gao & Shaokai Ning & Jinfeng Shang & Ruiyuan Guo & Yingying Chen & Britny Blumenfeld & Itamar Simon & Qing Li & Rong Guo & Dongyi Xu, 2022. "RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    8. Jian Ma & Yingke Zhou & Penglin Pan & Haixin Yu & Zixi Wang & Lei Lily Li & Bing Wang & Yuqian Yan & Yunqian Pan & Qi Ye & Tianjie Liu & Xiaoyu Feng & Shan Xu & Ke Wang & Xinyang Wang & Yanlin Jian & , 2023. "TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    9. Jennifer B. Shah & Dana Pueschl & Bradley Wubbenhorst & Mengyao Fan & John Pluta & Kurt D’Andrea & Anna P. Hubert & Jake S. Shilan & Wenting Zhou & Adam A. Kraya & Alba Llop Guevara & Catherine Ruan &, 2022. "Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    10. Diego Dibitetto & Martin Liptay & Francesca Vivalda & Hülya Dogan & Ewa Gogola & Martín González Fernández & Alexandra Duarte & Jonas A. Schmid & Morgane Decollogny & Paola Francica & Sara Przetocka &, 2024. "H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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