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Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

Author

Listed:
  • Stephen G. Brohawn

    (Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA)

  • Ernest B. Campbell

    (Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA)

  • Roderick MacKinnon

    (Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA)

Abstract

X-ray structures of the human TRAAK mechanosensitive potassium channel reveal how build-up of tension in the lipid membrane can convert the channel from a non-conducting wedge shape associated with an inserted lipid acyl chain that blocks the pore to an expanded cross-sectional shape that prevents lipid entry and thus permits ion conduction.

Suggested Citation

  • Stephen G. Brohawn & Ernest B. Campbell & Roderick MacKinnon, 2014. "Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel," Nature, Nature, vol. 516(7529), pages 126-130, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7529:d:10.1038_nature14013
    DOI: 10.1038/nature14013
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    Citations

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    Cited by:

    1. Philipp A. M. Schmidpeter & John T. Petroff & Leila Khajoueinejad & Aboubacar Wague & Cheryl Frankfater & Wayland W. L. Cheng & Crina M. Nimigean & Paul M. Riegelhaupt, 2023. "Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Berke Türkaydin & Marcus Schewe & Elena Barbara Riel & Friederike Schulz & Johann Biedermann & Thomas Baukrowitz & Han Sun, 2024. "Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Yuanyue Shan & Mengmeng Zhang & Meiyu Chen & Xinyi Guo & Ying Li & Mingfeng Zhang & Duanqing Pei, 2024. "Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Jonathan Mount & Grigory Maksaev & Brock T. Summers & James A. J. Fitzpatrick & Peng Yuan, 2022. "Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Karin E. J. Rödström & Alexander Cloake & Janina Sörmann & Agnese Baronina & Kathryn H. M. Smith & Ashley C. W. Pike & Jackie Ang & Peter Proks & Marcus Schewe & Ingelise Holland-Kaye & Simon R. Bushe, 2024. "Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Martina Nicoletti & Letizia Chiodo & Alessandro Loppini, 2021. "Biophysics and Modeling of Mechanotransduction in Neurons: A Review," Mathematics, MDPI, vol. 9(4), pages 1-32, February.
    7. Mingfeng Zhang & Yuanyue Shan & Charles D. Cox & Duanqing Pei, 2023. "A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    8. Xiaofen Liu & Weiwei Wang, 2023. "Asymmetric gating of a human hetero-pentameric glycine receptor," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    9. Toby S. Turney & Vivian Li & Stephen G. Brohawn, 2022. "Structural Basis for pH-gating of the K+ channel TWIK1 at the selectivity filter," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    10. Marcos Matamoros & Xue Wen Ng & Joshua B. Brettmann & David W. Piston & Colin G. Nichols, 2023. "Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    11. Ben Sorum & Trevor Docter & Vincent Panico & Robert A. Rietmeijer & Stephen G. Brohawn, 2024. "Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    12. Zhihui He & Yonghui Zhao & Michael J. Rau & James A. J. Fitzpatrick & Rajan Sah & Hongzhen Hu & Peng Yuan, 2023. "Structural and functional analysis of human pannexin 2 channel," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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