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Piezo2 is the major transducer of mechanical forces for touch sensation in mice

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  • Sanjeev S. Ranade

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute)

  • Seung-Hyun Woo

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute)

  • Adrienne E. Dubin

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute)

  • Rabih A. Moshourab

    (Max-Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, D-13092 Berlin, Germany
    Klinik für Anästhesiologie mit Schwerpunkt Operative Intensivmedizin, Campus Charité Mitte and Virchow-Klinikum Charité, Universitätsmedizin Berlin, Augustburgerplatz 1, 13353 Berlin, Germany)

  • Christiane Wetzel

    (Max-Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, D-13092 Berlin, Germany)

  • Matt Petrus

    (Genomics Institute of the Novartis Research Foundation)

  • Jayanti Mathur

    (Genomics Institute of the Novartis Research Foundation)

  • Valérie Bégay

    (Max-Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, D-13092 Berlin, Germany)

  • Bertrand Coste

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute
    Present address: Ion Channels and Sensory Transduction group, Aix Marseille University, CNRS, CRN2M-UMR 7286, 13344 Marseille, France.)

  • James Mainquist

    (Genomics Institute of the Novartis Research Foundation)

  • A. J. Wilson

    (Genomics Institute of the Novartis Research Foundation)

  • Allain G. Francisco

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute)

  • Kritika Reddy

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute)

  • Zhaozhu Qiu

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute
    Genomics Institute of the Novartis Research Foundation)

  • John N. Wood

    (Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK)

  • Gary R. Lewin

    (Max-Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, D-13092 Berlin, Germany)

  • Ardem Patapoutian

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute)

Abstract

Mice lacking the mechanically activated ion channel Piezo2 in both sensory neurons and Merkel cells are almost totally incapable of light-touch sensation while other somatosensory functions, such as mechanical nociception, remain intact, implying that other mechanically activated ion channels must now be identified to account for painful touch sensation.

Suggested Citation

  • Sanjeev S. Ranade & Seung-Hyun Woo & Adrienne E. Dubin & Rabih A. Moshourab & Christiane Wetzel & Matt Petrus & Jayanti Mathur & Valérie Bégay & Bertrand Coste & James Mainquist & A. J. Wilson & Allai, 2014. "Piezo2 is the major transducer of mechanical forces for touch sensation in mice," Nature, Nature, vol. 516(7529), pages 121-125, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7529:d:10.1038_nature13980
    DOI: 10.1038/nature13980
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    Citations

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    Cited by:

    1. Jonathan Madar & Namrata Tiwari & Cristina Smith & Divya Sharma & Shanwei Shen & Alsiddig Elmahdi & Liya Y. Qiao, 2023. "Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Mayank Gautam & Akihiro Yamada & Ayaka I. Yamada & Qinxue Wu & Kim Kridsada & Jennifer Ling & Huasheng Yu & Peter Dong & Minghong Ma & Jianguo Gu & Wenqin Luo, 2024. "Distinct local and global functions of mouse Aβ low-threshold mechanoreceptors in mechanical nociception," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Alia M. Obeidat & Matthew J. Wood & Natalie S. Adamczyk & Shingo Ishihara & Jun Li & Lai Wang & Dongjun Ren & David A. Bennett & Richard J. Miller & Anne-Marie Malfait & Rachel E. Miller, 2023. "Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Luis O. Romero & Rebeca Caires & A. Kaitlyn Victor & Juanma Ramirez & Francisco J. Sierra-Valdez & Patrick Walsh & Vincent Truong & Jungsoo Lee & Ugo Mayor & Lawrence T. Reiter & Valeria Vásquez & Jul, 2023. "Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    5. Julia Ojeda-Alonso & Laura Calvo-Enrique & Ricardo Paricio-Montesinos & Rakesh Kumar & Ming-Dong Zhang & James F. A. Poulet & Patrik Ernfors & Gary R. Lewin, 2024. "Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Pei Wang & Katharine K. Miller & Enqi He & Siddhant S. Dhawan & Christopher L. Cunningham & Nicolas Grillet, 2024. "LOXHD1 is indispensable for maintaining TMC1 auditory mechanosensitive channels at the site of force transmission," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    7. Francisco Andrés Peralta & Mélaine Balcon & Adeline Martz & Deniza Biljali & Federico Cevoli & Benoit Arnould & Antoine Taly & Thierry Chataigneau & Thomas Grutter, 2023. "Optical control of PIEZO1 channels," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    8. Matthew Gabrielle & Yevgen Yudin & Yujue Wang & Xiaoyang Su & Tibor Rohacs, 2024. "Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    9. Amandeep Kaur & Madhu & Alok Sharma & Kashmir Singh & Santosh Kumar Upadhyay, 2023. "Exploration of Piezo Channels in Bread Wheat ( Triticum aestivum L.)," Agriculture, MDPI, vol. 13(4), pages 1-16, March.
    10. Martina Nicoletti & Letizia Chiodo & Alessandro Loppini, 2021. "Biophysics and Modeling of Mechanotransduction in Neurons: A Review," Mathematics, MDPI, vol. 9(4), pages 1-32, February.
    11. Clement Verkest & Irina Schaefer & Timo A. Nees & Na Wang & Juri M. Jegelka & Francisco J. Taberner & Stefan G. Lechner, 2022. "Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    12. Gregory J Gerling & Lingtian Wan & Benjamin U Hoffman & Yuxiang Wang & Ellen A Lumpkin, 2018. "Computation predicts rapidly adapting mechanotransduction currents cannot account for tactile encoding in Merkel cell-neurite complexes," PLOS Computational Biology, Public Library of Science, vol. 14(6), pages 1-21, June.

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