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The complete structure of the large subunit of the mammalian mitochondrial ribosome

Author

Listed:
  • Basil J. Greber

    (Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, ETH Zurich, CH-8093 Zurich, Switzerland)

  • Daniel Boehringer

    (Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, ETH Zurich, CH-8093 Zurich, Switzerland)

  • Marc Leibundgut

    (Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, ETH Zurich, CH-8093 Zurich, Switzerland)

  • Philipp Bieri

    (Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, ETH Zurich, CH-8093 Zurich, Switzerland)

  • Alexander Leitner

    (Institute of Molecular Systems Biology, Auguste-Piccard-Hof 1, ETH Zurich, CH-8093 Zurich, Switzerland)

  • Nikolaus Schmitz

    (Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, ETH Zurich, CH-8093 Zurich, Switzerland)

  • Ruedi Aebersold

    (Institute of Molecular Systems Biology, Auguste-Piccard-Hof 1, ETH Zurich, CH-8093 Zurich, Switzerland
    Faculty of Science, University of Zurich, CH-8057 Zurich, Switzerland)

  • Nenad Ban

    (Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, ETH Zurich, CH-8093 Zurich, Switzerland)

Abstract

The structure of the 39S large mitoribosome subunit is solved by cryo-electron microscopy at an impressive 3.4 Å resolution, revealing the location of 50 ribosomal proteins, the peptidyl transferase centre, the tRNAs within this active site, and the nascent peptide chain within the exit tunnel.

Suggested Citation

  • Basil J. Greber & Daniel Boehringer & Marc Leibundgut & Philipp Bieri & Alexander Leitner & Nikolaus Schmitz & Ruedi Aebersold & Nenad Ban, 2014. "The complete structure of the large subunit of the mammalian mitochondrial ribosome," Nature, Nature, vol. 515(7526), pages 283-286, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7526:d:10.1038_nature13895
    DOI: 10.1038/nature13895
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    Cited by:

    1. Thu Giang Nguyen & Christina Ritter & Eva Kummer, 2023. "Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Victor Tobiasson & Ieva Berzina & Alexey Amunts, 2022. "Structure of a mitochondrial ribosome with fragmented rRNA in complex with membrane-targeting elements," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Vivek Singh & Yuzuru Itoh & Samuel Del’Olio & Asem Hassan & Andreas Naschberger & Rasmus Kock Flygaard & Yuko Nobe & Keiichi Izumikawa & Shintaro Aibara & Juni Andréll & Paul C. Whitford & Antoni Barr, 2024. "Mitoribosome structure with cofactors and modifications reveals mechanism of ligand binding and interactions with L1 stalk," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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