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Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA

Author

Listed:
  • Emilia Huerta-Sánchez

    (BGI-Shenzhen
    University of California
    School of Natural Sciences, University of California)

  • Xin Jin

    (BGI-Shenzhen
    School of Bioscience and Bioengineering, South China University of Technology)

  • Asan

    (BGI-Shenzhen
    Binhai Genomics Institute, BGI-Tianjin, Tianjin 300308, China
    Tianjin Translational Genomics Center, BGI-Tianjin, Tianjin 300308, China)

  • Zhuoma Bianba

    (The People’s Hospital of Lhasa)

  • Benjamin M. Peter

    (University of California)

  • Nicolas Vinckenbosch

    (University of California)

  • Yu Liang

    (BGI-Shenzhen
    Binhai Genomics Institute, BGI-Tianjin, Tianjin 300308, China
    Tianjin Translational Genomics Center, BGI-Tianjin, Tianjin 300308, China)

  • Xin Yi

    (BGI-Shenzhen
    Binhai Genomics Institute, BGI-Tianjin, Tianjin 300308, China
    Tianjin Translational Genomics Center, BGI-Tianjin, Tianjin 300308, China)

  • Mingze He

    (BGI-Shenzhen
    Bioinformatics and Computational Biology Program, Iowa State University)

  • Mehmet Somel

    (Middle East Technical University, 06800 Ankara, Turkey)

  • Peixiang Ni

    (BGI-Shenzhen)

  • Bo Wang

    (BGI-Shenzhen)

  • Xiaohua Ou

    (BGI-Shenzhen)

  • Huasang

    (BGI-Shenzhen)

  • Jiangbai Luosang

    (BGI-Shenzhen)

  • Zha Xi Ping Cuo

    (The Second People’s Hospital of Tibet Autonomous Region)

  • Kui Li

    (The People's Hospital of the Tibet Autonomous Region)

  • Guoyi Gao

    (The hospital of XiShuangBanNa Dai Nationalities, Autonomous Jinghong)

  • Ye Yin

    (BGI-Shenzhen)

  • Wei Wang

    (BGI-Shenzhen)

  • Xiuqing Zhang

    (BGI-Shenzhen
    The Guangdong Enterprise Key Laboratory of Human Disease Genomics, BGI-Shenzhen, 518083 Shenzhen, China
    Shenzhen Key Laboratory of Transomics Biotechnologies, BGI-Shenzhen, 518083 Shenzhen, China)

  • Xun Xu

    (BGI-Shenzhen)

  • Huanming Yang

    (BGI-Shenzhen
    Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University
    James D. Watson Institute of Genome Science)

  • Yingrui Li

    (BGI-Shenzhen)

  • Jian Wang

    (BGI-Shenzhen
    James D. Watson Institute of Genome Science)

  • Jun Wang

    (BGI-Shenzhen
    Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University
    University of Copenhagen, Ole MaaløesVej 5, 2200 Copenhagen, Denmark
    Macau University of Science and Technology, AvenidaWai long, Taipa, Macau 999078, China)

  • Rasmus Nielsen

    (BGI-Shenzhen
    University of California
    University of California
    University of Copenhagen, 2200 Copenhagen, Denmark)

Abstract

Admixture with other hominin species helped humans to adapt to high-altitude environments; the EPAS1 gene in Tibetan individuals has an unusual haplotype structure that probably resulted from introgression of DNA from Denisovan or Denisovan-related individuals into humans, and this haplotype is only found in Denisovans and Tibetans, and at low frequency among Han Chinese.

Suggested Citation

  • Emilia Huerta-Sánchez & Xin Jin & Asan & Zhuoma Bianba & Benjamin M. Peter & Nicolas Vinckenbosch & Yu Liang & Xin Yi & Mingze He & Mehmet Somel & Peixiang Ni & Bo Wang & Xiaohua Ou & Huasang & Jiangb, 2014. "Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA," Nature, Nature, vol. 512(7513), pages 194-197, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7513:d:10.1038_nature13408
    DOI: 10.1038/nature13408
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    Citations

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    Cited by:

    1. Shan Liu & Xuhua Li & Qing Lin & Jiang Qiu, 2023. "Spatial Distribution of Ethnic Villages in the Mountainous Region of Northwest Yunnan and Their Relationship with Natural Factors," Sustainability, MDPI, vol. 15(16), pages 1-19, August.
    2. Biao-Feng Zhou & Shuai Yuan & Andrew A. Crowl & Yi-Ye Liang & Yong Shi & Xue-Yan Chen & Qing-Qing An & Ming Kang & Paul S. Manos & Baosheng Wang, 2022. "Phylogenomic analyses highlight innovation and introgression in the continental radiations of Fagaceae across the Northern Hemisphere," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Ningbo Chen & Xiaoting Xia & Quratulain Hanif & Fengwei Zhang & Ruihua Dang & Bizhi Huang & Yang Lyu & Xiaoyu Luo & Hucai Zhang & Huixuan Yan & Shikang Wang & Fuwen Wang & Jialei Chen & Xiwen Guan & Y, 2023. "Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Jinlong Shi & Zhilong Jia & Jinxiu Sun & Xiaoreng Wang & Xiaojing Zhao & Chenghui Zhao & Fan Liang & Xinyu Song & Jiawei Guan & Xue Jia & Jing Yang & Qi Chen & Kang Yu & Qian Jia & Jing Wu & Depeng Wa, 2023. "Structural variants involved in high-altitude adaptation detected using single-molecule long-read sequencing," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Chi-Chun Liu & David Witonsky & Anna Gosling & Ju Hyeon Lee & Harald Ringbauer & Richard Hagan & Nisha Patel & Raphaela Stahl & John Novembre & Mark Aldenderfer & Christina Warinner & Anna Di Rienzo &, 2022. "Ancient genomes from the Himalayas illuminate the genetic history of Tibetans and their Tibeto-Burman speaking neighbors," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    6. Julian Petersen & Lukas Englmaier & Artem V. Artemov & Irina Poverennaya & Ruba Mahmoud & Thibault Bouderlique & Marketa Tesarova & Ruslan Deviatiiarov & Anett Szilvásy-Szabó & Evgeny E. Akkuratov & D, 2023. "A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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