IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v510y2014i7503d10.1038_nature13474.html
   My bibliography  Save this article

Lipid landscapes and pipelines in membrane homeostasis

Author

Listed:
  • Joost C.M. Holthuis

    (Fachbereich Biologie/Chemie, University of Osnabrück
    Membrane Biochemistry & Biophysics, Bijvoet Center for Biomolecular Research and Institute of Biomembranes, Utrecht University)

  • Anant K. Menon

    (Weill Cornell Medical College)

Abstract

The lipid composition of cellular organelles is tailored to suit their specialized tasks. A fundamental transition in the lipid landscape divides the secretory pathway in early and late membrane territories, allowing an adaptation from biogenic to barrier functions. Defending the contrasting features of these territories against erosion by vesicular traffic poses a major logistical problem. To this end, cells evolved a network of lipid composition sensors and pipelines along which lipids are moved by non-vesicular mechanisms. We review recent insights into the molecular basis of this regulatory network and consider examples in which malfunction of its components leads to system failure and disease.

Suggested Citation

  • Joost C.M. Holthuis & Anant K. Menon, 2014. "Lipid landscapes and pipelines in membrane homeostasis," Nature, Nature, vol. 510(7503), pages 48-57, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7503:d:10.1038_nature13474
    DOI: 10.1038/nature13474
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13474
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13474?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Dmitry Shvarev & Caroline König & Nicole Susan & Lars Langemeyer & Stefan Walter & Angela Perz & Florian Fröhlich & Christian Ungermann & Arne Moeller, 2024. "Structure of the endosomal CORVET tethering complex," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Diede Haan & Lior Aram & Hadas Peled-Zehavi & Yoseph Addadi & Oz Ben-Joseph & Ron Rotkopf & Nadav Elad & Katya Rechav & Assaf Gal, 2023. "Exocytosis of the silicified cell wall of diatoms involves extensive membrane disintegration," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Yoko Ito & Nicolas Esnay & Matthieu Pierre Platre & Valérie Wattelet-Boyer & Lise C. Noack & Louise Fougère & Wilhelm Menzel & Stéphane Claverol & Laetitia Fouillen & Patrick Moreau & Yvon Jaillais & , 2021. "Sphingolipids mediate polar sorting of PIN2 through phosphoinositide consumption at the trans-Golgi network," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    4. Leslie A. Rowland & Adilson Guilherme & Felipe Henriques & Chloe DiMarzio & Sean Munroe & Nicole Wetoska & Mark Kelly & Keith Reddig & Gregory Hendricks & Meixia Pan & Xianlin Han & Olga R. Ilkayeva &, 2023. "De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Darshini Jeyasimman & Bilge Ercan & Dennis Dharmawan & Tomoki Naito & Jingbo Sun & Yasunori Saheki, 2021. "PDZD-8 and TEX-2 regulate endosomal PI(4,5)P2 homeostasis via lipid transport to promote embryogenesis in C. elegans," Nature Communications, Nature, vol. 12(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:510:y:2014:i:7503:d:10.1038_nature13474. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.