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Lipid landscapes and pipelines in membrane homeostasis

Author

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  • Joost C.M. Holthuis

    (Fachbereich Biologie/Chemie, University of Osnabrück
    Membrane Biochemistry & Biophysics, Bijvoet Center for Biomolecular Research and Institute of Biomembranes, Utrecht University)

  • Anant K. Menon

    (Weill Cornell Medical College)

Abstract

The lipid composition of cellular organelles is tailored to suit their specialized tasks. A fundamental transition in the lipid landscape divides the secretory pathway in early and late membrane territories, allowing an adaptation from biogenic to barrier functions. Defending the contrasting features of these territories against erosion by vesicular traffic poses a major logistical problem. To this end, cells evolved a network of lipid composition sensors and pipelines along which lipids are moved by non-vesicular mechanisms. We review recent insights into the molecular basis of this regulatory network and consider examples in which malfunction of its components leads to system failure and disease.

Suggested Citation

  • Joost C.M. Holthuis & Anant K. Menon, 2014. "Lipid landscapes and pipelines in membrane homeostasis," Nature, Nature, vol. 510(7503), pages 48-57, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7503:d:10.1038_nature13474
    DOI: 10.1038/nature13474
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    Cited by:

    1. Yannick Weyer & Sinead I. Schwabl & Xuechen Tang & Astha Purwar & Konstantin Siegmann & Angela Ruepp & Theresia Dunzendorfer-Matt & Michael A. Widerin & Veronika Niedrist & Noa J. M. Mutsters & Maria , 2024. "The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Dmitry Shvarev & Caroline König & Nicole Susan & Lars Langemeyer & Stefan Walter & Angela Perz & Florian Fröhlich & Christian Ungermann & Arne Moeller, 2024. "Structure of the endosomal CORVET tethering complex," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Diede Haan & Lior Aram & Hadas Peled-Zehavi & Yoseph Addadi & Oz Ben-Joseph & Ron Rotkopf & Nadav Elad & Katya Rechav & Assaf Gal, 2023. "Exocytosis of the silicified cell wall of diatoms involves extensive membrane disintegration," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Yoko Ito & Nicolas Esnay & Matthieu Pierre Platre & Valérie Wattelet-Boyer & Lise C. Noack & Louise Fougère & Wilhelm Menzel & Stéphane Claverol & Laetitia Fouillen & Patrick Moreau & Yvon Jaillais & , 2021. "Sphingolipids mediate polar sorting of PIN2 through phosphoinositide consumption at the trans-Golgi network," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    5. Leslie A. Rowland & Adilson Guilherme & Felipe Henriques & Chloe DiMarzio & Sean Munroe & Nicole Wetoska & Mark Kelly & Keith Reddig & Gregory Hendricks & Meixia Pan & Xianlin Han & Olga R. Ilkayeva &, 2023. "De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Darshini Jeyasimman & Bilge Ercan & Dennis Dharmawan & Tomoki Naito & Jingbo Sun & Yasunori Saheki, 2021. "PDZD-8 and TEX-2 regulate endosomal PI(4,5)P2 homeostasis via lipid transport to promote embryogenesis in C. elegans," Nature Communications, Nature, vol. 12(1), pages 1-21, December.

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