IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v508y2014i7494d10.1038_nature13110.html
   My bibliography  Save this article

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

Author

Listed:
  • Kıvanç Birsoy

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    Broad Institute of Harvard and MIT, Seven Cambridge Center
    The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue)

  • Richard Possemato

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    Broad Institute of Harvard and MIT, Seven Cambridge Center
    The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue)

  • Franziska K. Lorbeer

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center)

  • Erol C. Bayraktar

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center)

  • Prathapan Thiru

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center)

  • Burcu Yucel

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center)

  • Tim Wang

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    Broad Institute of Harvard and MIT, Seven Cambridge Center
    The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue)

  • Walter W. Chen

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    Broad Institute of Harvard and MIT, Seven Cambridge Center
    The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue)

  • Clary B. Clish

    (Broad Institute of Harvard and MIT, Seven Cambridge Center)

  • David M. Sabatini

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    Broad Institute of Harvard and MIT, Seven Cambridge Center
    The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue)

Abstract

New apparatus is used to maintain proliferating cancer cells in low-glucose conditions, demonstrating that mitochondrial oxidative phosphorylation (OXPHOS) is essential for optimal proliferation in these conditions; the most sensitive cell lines are defective in OXPHOS upregulation and may therefore be sensitive to current antidiabetic drugs that inhibit OXPHOS.

Suggested Citation

  • Kıvanç Birsoy & Richard Possemato & Franziska K. Lorbeer & Erol C. Bayraktar & Prathapan Thiru & Burcu Yucel & Tim Wang & Walter W. Chen & Clary B. Clish & David M. Sabatini, 2014. "Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides," Nature, Nature, vol. 508(7494), pages 108-112, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7494:d:10.1038_nature13110
    DOI: 10.1038/nature13110
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13110
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13110?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shuaifeng Li & Shixun Han & Qi Zhang & Yibing Zhu & Haitao Zhang & Junli Wang & Yang Zhao & Jianhui Zhao & Lin Su & Li Li & Dawang Zhou & Cunqi Ye & Xin-Hua Feng & Tingbo Liang & Bin Zhao, 2022. "FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Yuanli Zhen & Kai Liu & Lei Shi & Simran Shah & Qin Xu & Haley Ellis & Eranga R. Balasooriya & Johannes Kreuzer & Robert Morris & Albert S. Baldwin & Dejan Juric & Wilhelm Haas & Nabeel Bardeesy, 2024. "FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Xianbing Zhu & Zheng Fu & Shary Y. Chen & Dionzie Ong & Giulio Aceto & Rebecca Ho & Jutta Steinberger & Anie Monast & Virginie Pilon & Eunice Li & Monica Ta & Kyle Ching & Bianca N. Adams & Gian L. Ne, 2023. "Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Xin Yuan & Yanran Ma & Ruitian Gao & Shuya Cui & Yifan Wang & Botao Fa & Shiyang Ma & Ting Wei & Shuangge Ma & Zhangsheng Yu, 2024. "HEARTSVG: a fast and accurate method for identifying spatially variable genes in large-scale spatial transcriptomics," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Marc Hennequart & Christiaan F. Labuschagne & Mylène Tajan & Steven E. Pilley & Eric C. Cheung & Nathalie M. Legrave & Paul C. Driscoll & Karen H. Vousden, 2021. "The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells," Nature Communications, Nature, vol. 12(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:508:y:2014:i:7494:d:10.1038_nature13110. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.