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D14–SCFD3-dependent degradation of D53 regulates strigolactone signalling

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  • Feng Zhou

    (National Key Laboratory for Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University
    National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Qibing Lin

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Lihong Zhu

    (National Key Laboratory for Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University)

  • Yulong Ren

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Kunneng Zhou

    (National Key Laboratory for Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University)

  • Nitzan Shabek

    (University of Washington
    Howard Hughes Medical Institute, Box 357280, University of Washington)

  • Fuqing Wu

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Haibin Mao

    (University of Washington
    Howard Hughes Medical Institute, Box 357280, University of Washington)

  • Wei Dong

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Lu Gan

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Weiwei Ma

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • He Gao

    (National Key Laboratory for Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University)

  • Jun Chen

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Chao Yang

    (National Key Laboratory for Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University)

  • Dan Wang

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Junjie Tan

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Xin Zhang

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Xiuping Guo

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Jiulin Wang

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Ling Jiang

    (National Key Laboratory for Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University)

  • Xi Liu

    (National Key Laboratory for Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University)

  • Weiqi Chen

    (National Centre for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 1-2 Beichen West Road, Beijing 100101, China)

  • Jinfang Chu

    (National Centre for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 1-2 Beichen West Road, Beijing 100101, China)

  • Cunyu Yan

    (National Centre for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 1-2 Beichen West Road, Beijing 100101, China)

  • Kotomi Ueno

    (The University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan)

  • Shinsaku Ito

    (The University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan)

  • Tadao Asami

    (The University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan)

  • Zhijun Cheng

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Jie Wang

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Cailin Lei

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Huqu Zhai

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Chuanyin Wu

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Haiyang Wang

    (National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Ning Zheng

    (University of Washington
    Howard Hughes Medical Institute, Box 357280, University of Washington)

  • Jianmin Wan

    (National Key Laboratory for Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University
    National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences)

Abstract

Strigolactones (SLs), a newly discovered class of carotenoid-derived phytohormones, are essential for developmental processes that shape plant architecture and interactions with parasitic weeds and symbiotic arbuscular mycorrhizal fungi. Despite the rapid progress in elucidating the SL biosynthetic pathway, the perception and signalling mechanisms of SL remain poorly understood. Here we show that DWARF 53 (D53) acts as a repressor of SL signalling and that SLs induce its degradation. We find that the rice (Oryza sativa) d53 mutant, which produces an exaggerated number of tillers compared to wild-type plants, is caused by a gain-of-function mutation and is insensitive to exogenous SL treatment. The D53 gene product shares predicted features with the class I Clp ATPase proteins and can form a complex with the α/β hydrolase protein DWARF 14 (D14) and the F-box protein DWARF 3 (D3), two previously identified signalling components potentially responsible for SL perception. We demonstrate that, in a D14- and D3-dependent manner, SLs induce D53 degradation by the proteasome and abrogate its activity in promoting axillary bud outgrowth. Our combined genetic and biochemical data reveal that D53 acts as a repressor of the SL signalling pathway, whose hormone-induced degradation represents a key molecular link between SL perception and responses.

Suggested Citation

  • Feng Zhou & Qibing Lin & Lihong Zhu & Yulong Ren & Kunneng Zhou & Nitzan Shabek & Fuqing Wu & Haibin Mao & Wei Dong & Lu Gan & Weiwei Ma & He Gao & Jun Chen & Chao Yang & Dan Wang & Junjie Tan & Xin Z, 2013. "D14–SCFD3-dependent degradation of D53 regulates strigolactone signalling," Nature, Nature, vol. 504(7480), pages 406-410, December.
  • Handle: RePEc:nat:nature:v:504:y:2013:i:7480:d:10.1038_nature12878
    DOI: 10.1038/nature12878
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    Cited by:

    1. Eva-Sophie Wallner & Nina Tonn & Dongbo Shi & Laura Luzzietti & Friederike Wanke & Pascal Hunziker & Yingqiang Xu & Ilona Jung & Vadir Lopéz-Salmerón & Michael Gebert & Christian Wenzl & Jan U. Lohman, 2023. "OBERON3 and SUPPRESSOR OF MAX2 1-LIKE proteins form a regulatory module driving phloem development," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Kyoichi Kodama & Mélanie K. Rich & Akiyoshi Yoda & Shota Shimazaki & Xiaonan Xie & Kohki Akiyama & Yohei Mizuno & Aino Komatsu & Yi Luo & Hidemasa Suzuki & Hiromu Kameoka & Cyril Libourel & Jean Kelle, 2022. "An ancestral function of strigolactones as symbiotic rhizosphere signals," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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