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Cortical interneurons that specialize in disinhibitory control

Author

Listed:
  • Hyun-Jae Pi

    (Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Balázs Hangya

    (Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary)

  • Duda Kvitsiani

    (Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Joshua I. Sanders

    (Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Z. Josh Huang

    (Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Adam Kepecs

    (Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

Abstract

Cortical inhibitory interneurons expressing vasoactive intestinal polypeptide (VIP) are shown to specialize in suppressing the activity of other inhibitory interneurons and are activated by reinforcement signals, thus increasing the activity of excitatory neurons by releasing them from inhibition; these results reveal a cell-type-specific microcircuit that tunes cortical activity under certain behavioural conditions.

Suggested Citation

  • Hyun-Jae Pi & Balázs Hangya & Duda Kvitsiani & Joshua I. Sanders & Z. Josh Huang & Adam Kepecs, 2013. "Cortical interneurons that specialize in disinhibitory control," Nature, Nature, vol. 503(7477), pages 521-524, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7477:d:10.1038_nature12676
    DOI: 10.1038/nature12676
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    Cited by:

    1. XiaoYuan Li & XiaoLi Yang & ZhongKui Sun, 2020. "Alpha rhythm slowing in a modified thalamo-cortico-thalamic model related with Alzheimer’s disease," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-22, March.
    2. Nicholas Cole & Matthew Harvey & Dylan Myers-Joseph & Aditya Gilra & Adil G. Khan, 2024. "Prediction-error signals in anterior cingulate cortex drive task-switching," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Zhihui Wang & Manhong Xie, 2023. "Kinetic analysis of spike and wave discharge in a neural mass model," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 96(7), pages 1-12, July.
    4. Kaizhen Li & Konstantinos Koukoutselos & Masanori Sakaguchi & Stéphane Ciocchi, 2024. "Distinct ventral hippocampal inhibitory microcircuits regulating anxiety and fear behaviors," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Sudesna Chakraborty & Roy A. M. Haast & Kate M. Onuska & Prabesh Kanel & Marco A. M. Prado & Vania F. Prado & Ali R. Khan & Taylor W. Schmitz, 2024. "Multimodal gradients of basal forebrain connectivity across the neocortex," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Yanmei Liu & Jiahe Zhang & Zhishan Jiang & Meiling Qin & Min Xu & Siyu Zhang & Guofen Ma, 2024. "Organization of corticocortical and thalamocortical top-down inputs in the primary visual cortex," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    7. Panna Hegedüs & Bálint Király & Dániel Schlingloff & Victoria Lyakhova & Anna Velencei & Írisz Szabó & Márton I. Mayer & Zsofia Zelenak & Gábor Nyiri & Balázs Hangya, 2024. "Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    8. Mohamad Motaharinia & Kim Gerrow & Roobina Boghozian & Emily White & Sun-Eui Choi & Kerry R. Delaney & Craig E. Brown, 2021. "Longitudinal functional imaging of VIP interneurons reveals sup-population specific effects of stroke that are rescued with chemogenetic therapy," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    9. Robert Legenstein & Wolfgang Maass, 2014. "Ensembles of Spiking Neurons with Noise Support Optimal Probabilistic Inference in a Dynamically Changing Environment," PLOS Computational Biology, Public Library of Science, vol. 10(10), pages 1-27, October.
    10. Tristan G. Heintz & Antonio J. Hinojosa & Sina E. Dominiak & Leon Lagnado, 2022. "Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    11. Yue Liu & Xiao-Jing Wang, 2024. "Flexible gating between subspaces in a neural network model of internally guided task switching," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    12. Yan, Luyao & Zhang, Honghui & Sun, Zhongkui & Liu, Shuang & Liu, Yuanyuan & Xiao, Pengcheng, 2022. "Optimization of stimulation waveforms for regulating spike-wave discharges in a thalamocortical model," Chaos, Solitons & Fractals, Elsevier, vol. 158(C).

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