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Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

Author

Listed:
  • Atsuya Nishiyama

    (Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan)

  • Luna Yamaguchi

    (Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan)

  • Jafar Sharif

    (RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan)

  • Yoshikazu Johmura

    (Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan)

  • Takeshi Kawamura

    (Laboratory for System Biology and Medicine, RCAST, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8904, Japan)

  • Keiko Nakanishi

    (Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan)

  • Shintaro Shimamura

    (Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan)

  • Kyohei Arita

    (Graduate School of Medical Life Sciences, Yokohama City University, 1-7-29, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan)

  • Tatsuhiko Kodama

    (Laboratory for System Biology and Medicine, RCAST, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8904, Japan)

  • Fuyuki Ishikawa

    (Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Haruhiko Koseki

    (RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan)

  • Makoto Nakanishi

    (Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan)

Abstract

The RING finger domain protein Uhrf1 is known to have an important role in DNA methylation pattern maintenance through the recruitment of the methyltransferase Dnmt1 to hemimethylated DNA sites: here, Uhrf1 is shown to act as a ubiquitin ligase for H3, an essential step in Dnmt1 recruitment.

Suggested Citation

  • Atsuya Nishiyama & Luna Yamaguchi & Jafar Sharif & Yoshikazu Johmura & Takeshi Kawamura & Keiko Nakanishi & Shintaro Shimamura & Kyohei Arita & Tatsuhiko Kodama & Fuyuki Ishikawa & Haruhiko Koseki & M, 2013. "Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication," Nature, Nature, vol. 502(7470), pages 249-253, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7470:d:10.1038_nature12488
    DOI: 10.1038/nature12488
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    Citations

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    Cited by:

    1. Kosuke Yamaguchi & Xiaoying Chen & Brianna Rodgers & Fumihito Miura & Pavel Bashtrykov & Frédéric Bonhomme & Catalina Salinas-Luypaert & Deis Haxholli & Nicole Gutekunst & Bihter Özdemir Aygenli & Lau, 2024. "Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Amika Kikuchi & Hiroki Onoda & Kosuke Yamaguchi & Satomi Kori & Shun Matsuzawa & Yoshie Chiba & Shota Tanimoto & Sae Yoshimi & Hiroki Sato & Atsushi Yamagata & Mikako Shirouzu & Naruhiko Adachi & Jafa, 2022. "Structural basis for activation of DNMT1," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Zengyu Shao & Jiuwei Lu & Nelli Khudaverdyan & Jikui Song, 2024. "Multi-layered heterochromatin interaction as a switch for DIM2-mediated DNA methylation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Satoshi Kaito & Kazumasa Aoyama & Motohiko Oshima & Akiho Tsuchiya & Makiko Miyota & Masayuki Yamashita & Shuhei Koide & Yaeko Nakajima-Takagi & Hiroko Kozuka-Hata & Masaaki Oyama & Takao Yogo & Tomoh, 2024. "Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. Lianmei Tan & Tao Yin & Handan Xiang & Liuyang Wang & Poorva Mudgal & Junying Chen & Yi Ding & Guoping Wang & Bryan Jian Wei Lim & Yuqi Huang & De Huang & Yaosi Liang & Peter B. Alexander & Kun Xiang , 2024. "Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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