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Pyrimidine homeostasis is accomplished by directed overflow metabolism

Author

Listed:
  • Marshall Louis Reaves

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Brian D. Young

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Aaron M. Hosios

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Yi-Fan Xu

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Joshua D. Rabinowitz

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University
    Princeton University)

Abstract

Here, the authors identify a previously unknown regulatory strategy used by Escherichia coli to control end-product levels of the pyrimidine biosynthetic pathway: this involves feedback regulation of the near-terminal pathway enzyme UMP kinase, with accumulation of UMP prevented by its degradation to uridine through UmpH, a phosphatase with a previously unknown function.

Suggested Citation

  • Marshall Louis Reaves & Brian D. Young & Aaron M. Hosios & Yi-Fan Xu & Joshua D. Rabinowitz, 2013. "Pyrimidine homeostasis is accomplished by directed overflow metabolism," Nature, Nature, vol. 500(7461), pages 237-241, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7461:d:10.1038_nature12445
    DOI: 10.1038/nature12445
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    Cited by:

    1. Kevin K. Y. Hu & Ankita Suri & Geoff Dumsday & Victoria S. Haritos, 2024. "Cross-feeding promotes heterogeneity within yeast cell populations," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Ida Lauritsen & Pernille Ott Frendorf & Silvia Capucci & Sophia A. H. Heyde & Sarah D. Blomquist & Sofie Wendel & Emil C. Fischer & Agnieszka Sekowska & Antoine Danchin & Morten H. H. Nørholm, 2021. "Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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