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High-level semi-synthetic production of the potent antimalarial artemisinin

Author

Listed:
  • C. J. Paddon

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • P. J. Westfall

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • D. J. Pitera

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • K. Benjamin

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • K. Fisher

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • D. McPhee

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • M. D. Leavell

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • A. Tai

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • A. Main

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • D. Eng

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • D. R. Polichuk

    (National Research Council of Canada, 110 Gymnasium Place)

  • K. H. Teoh

    (National Research Council of Canada, 110 Gymnasium Place
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • D. W. Reed

    (National Research Council of Canada, 110 Gymnasium Place)

  • T. Treynor

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • J. Lenihan

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • H. Jiang

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • M. Fleck

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • S. Bajad

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • G. Dang

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • D. Dengrove

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • D. Diola

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • G. Dorin

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • K. W. Ellens

    (National Research Council of Canada, 110 Gymnasium Place
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • S. Fickes

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • J. Galazzo

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • S. P. Gaucher

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • T. Geistlinger

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • R. Henry

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • M. Hepp

    (National Research Council of Canada, 110 Gymnasium Place
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • T. Horning

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • T. Iqbal

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • L. Kizer

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • B. Lieu

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • D. Melis

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • N. Moss

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • R. Regentin

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • S. Secrest

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • H. Tsuruta

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • R. Vazquez

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • L. F. Westblade

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • L. Xu

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • M. Yu

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • Y. Zhang

    (National Research Council of Canada, 110 Gymnasium Place
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • L. Zhao

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • J. Lievense

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • P. S. Covello

    (National Research Council of Canada, 110 Gymnasium Place)

  • J. D. Keasling

    (University of California
    University of California
    Lawrence Berkeley National Laboratory
    Joint BioEnergy Institute, 5885 Hollis Street)

  • K. K. Reiling

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • N. S. Renninger

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • J. D. Newman

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

Abstract

Saccharomyces cerevisiae is engineered to produce high concentrations of artemisinic acid, a precursor of the artemisinin used in combination therapies for malaria treatment; an efficient and practical chemical process to convert artemisinic acid to artemisinin is also developed.

Suggested Citation

  • C. J. Paddon & P. J. Westfall & D. J. Pitera & K. Benjamin & K. Fisher & D. McPhee & M. D. Leavell & A. Tai & A. Main & D. Eng & D. R. Polichuk & K. H. Teoh & D. W. Reed & T. Treynor & J. Lenihan & H., 2013. "High-level semi-synthetic production of the potent antimalarial artemisinin," Nature, Nature, vol. 496(7446), pages 528-532, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7446:d:10.1038_nature12051
    DOI: 10.1038/nature12051
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