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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Author

Listed:
  • Jaekyoung Son

    (Dana-Farber Cancer Institute)

  • Costas A. Lyssiotis

    (Harvard Medical School
    Beth Israel Deaconess Medical Center
    Present address: Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA.)

  • Haoqiang Ying

    (University of Texas MD Anderson Cancer Center)

  • Xiaoxu Wang

    (Dana-Farber Cancer Institute)

  • Sujun Hua

    (University of Texas MD Anderson Cancer Center)

  • Matteo Ligorio

    (Massachusetts General Hospital)

  • Rushika M. Perera

    (Cancer Center, Massachusetts General Hospital)

  • Cristina R. Ferrone

    (Massachusetts General Hospital)

  • Edouard Mullarky

    (Harvard Medical School
    Beth Israel Deaconess Medical Center
    Present address: Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA.)

  • Ng Shyh-Chang

    (Harvard Medical School
    Stem Cell Transplantation Program, Stem Cell Program, Children’s Hospital Boston and Dana Farber Cancer Institute)

  • Ya’an Kang

    (University of Texas MD Anderson Cancer Center)

  • Jason B. Fleming

    (University of Texas MD Anderson Cancer Center)

  • Nabeel Bardeesy

    (Cancer Center, Massachusetts General Hospital)

  • John M. Asara

    (Beth Israel Deaconess Medical Center
    Beth Israel Deaconess Medical Center)

  • Marcia C. Haigis

    (Harvard Medical School)

  • Ronald A. DePinho

    (University of Texas MD Anderson Cancer Center)

  • Lewis C. Cantley

    (Harvard Medical School
    Beth Israel Deaconess Medical Center
    Present address: Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA.)

  • Alec C. Kimmelman

    (Dana-Farber Cancer Institute)

Abstract

Pancreatic cancers use a novel glutamine metabolism pathway, regulated by oncogenic KRAS, to maintain redox balance; these findings add to the understanding of the mechanisms by which oncogenic alterations reprogram cellular metabolism to promote tumour growth.

Suggested Citation

  • Jaekyoung Son & Costas A. Lyssiotis & Haoqiang Ying & Xiaoxu Wang & Sujun Hua & Matteo Ligorio & Rushika M. Perera & Cristina R. Ferrone & Edouard Mullarky & Ng Shyh-Chang & Ya’an Kang & Jason B. Flem, 2013. "Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway," Nature, Nature, vol. 496(7443), pages 101-105, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7443:d:10.1038_nature12040
    DOI: 10.1038/nature12040
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    Cited by:

    1. Qiming Zhou & Yao Peng & Fenfen Ji & Huarong Chen & Wei Kang & Lam-Shing Chan & Hongyan Gou & Yufeng Lin & Pingmei Huang & Danyu Chen & Qinyao Wei & Hao Su & Cong Liang & Xiang Zhang & Jun Yu & Chi Ch, 2023. "Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Mahmoud A. Bassal & Saumya E. Samaraweera & Kelly Lim & Brooks A. Benard & Sheree Bailey & Satinder Kaur & Paul Leo & John Toubia & Chloe Thompson-Peach & Tran Nguyen & Kyaw Ze Ya Maung & Debora A. Ca, 2022. "Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Kimberley McGrail & Paula Granado-Martínez & Rosaura Esteve-Puig & Sara García-Ortega & Yuxin Ding & Sara Sánchez-Redondo & Berta Ferrer & Javier Hernandez-Losa & Francesc Canals & Anna Manzano & Aura, 2022. "BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    4. C. Megan Young & Laurent Beziaud & Pierre Dessen & Angela Madurga Alonso & Albert Santamaria-Martínez & Joerg Huelsken, 2023. "Metabolic dependencies of metastasis-initiating cells in female breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    5. Taiqi Chen & Siyi Xie & Jie Cheng & Qiao Zhao & Hong Wu & Peng Jiang & Wenjing Du, 2024. "AKT1 phosphorylation of cytoplasmic ME2 induces a metabolic switch to glycolysis for tumorigenesis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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