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Autophagosomes form at ER–mitochondria contact sites

Author

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  • Maho Hamasaki

    (Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Nobumichi Furuta

    (Center for Oral Frontier Science, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Atsushi Matsuda

    (National Institute of Information and Communications Technology, 588-2 Iwaoka, Iwaoka-cho, Nishi-ku, Kobe 651-2492, Japan
    Nuclear Dynamics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Akiko Nezu

    (Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Akitsugu Yamamoto

    (Faculty of Bio-Science, Nagahama Institute of Bio-Science and Technology, 1266 Tamura-cho, Nagahama, Shiga 526-0829, Japan)

  • Naonobu Fujita

    (Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Hiroko Oomori

    (Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Takeshi Noda

    (Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Tokuko Haraguchi

    (National Institute of Information and Communications Technology, 588-2 Iwaoka, Iwaoka-cho, Nishi-ku, Kobe 651-2492, Japan
    Nuclear Dynamics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Yasushi Hiraoka

    (National Institute of Information and Communications Technology, 588-2 Iwaoka, Iwaoka-cho, Nishi-ku, Kobe 651-2492, Japan
    Nuclear Dynamics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Atsuo Amano

    (Center for Oral Frontier Science, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan
    Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Tamotsu Yoshimori

    (Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan)

Abstract

This study shows that autophagosomes form at sites of contact between the endoplasmic reticulum and mitochondria, and that formation requires the SNARE protein syntaxin 17.

Suggested Citation

  • Maho Hamasaki & Nobumichi Furuta & Atsushi Matsuda & Akiko Nezu & Akitsugu Yamamoto & Naonobu Fujita & Hiroko Oomori & Takeshi Noda & Tokuko Haraguchi & Yasushi Hiraoka & Atsuo Amano & Tamotsu Yoshimo, 2013. "Autophagosomes form at ER–mitochondria contact sites," Nature, Nature, vol. 495(7441), pages 389-393, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7441:d:10.1038_nature11910
    DOI: 10.1038/nature11910
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    Cited by:

    1. Keisuke Tabata & Kenta Imai & Koki Fukuda & Kentaro Yamamoto & Hayato Kunugi & Toshiharu Fujita & Tatsuya Kaminishi & Christian Tischer & Beate Neumann & Sabine Reither & Fatima Verissimo & Rainer Pep, 2024. "Palmitoylation of ULK1 by ZDHHC13 plays a crucial role in autophagy," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Ji-Man Park & Da-Hye Lee & Do-Hyung Kim, 2023. "Redefining the role of AMPK in autophagy and the energy stress response," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Elodie Mailler & Carlos M. Guardia & Xiaofei Bai & Michal Jarnik & Chad D. Williamson & Yan Li & Nunziata Maio & Andy Golden & Juan S. Bonifacino, 2021. "The autophagy protein ATG9A enables lipid mobilization from lipid droplets," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    4. Chengyang Li & Patrick Duckney & Tong Zhang & Yanshu Fu & Xin Li & Johan Kroon & Geert Jaeger & Yunjiang Cheng & Patrick J. Hussey & Pengwei Wang, 2022. "TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Viola Nähse & Camilla Raiborg & Kia Wee Tan & Sissel Mørk & Maria Lyngaas Torgersen & Eva Maria Wenzel & Mireia Nager & Veijo T. Salo & Terje Johansen & Elina Ikonen & Kay Oliver Schink & Harald Stenm, 2023. "ATPase activity of DFCP1 controls selective autophagy," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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