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High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome

Author

Listed:
  • Yaser Hashem

    (Howard Hughes Medical Institute (HHMI), Columbia University)

  • Amedee des Georges

    (Howard Hughes Medical Institute (HHMI), Columbia University)

  • Jie Fu

    (Columbia University)

  • Sarah N. Buss

    (Wadsworth Center)

  • Fabrice Jossinet

    (Architecture et Réactivité de l’ARN, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire (CNRS))

  • Amy Jobe

    (Columbia University)

  • Qin Zhang

    (Institute for Computational Engineering and Sciences, University of Texas)

  • Hstau Y. Liao

    (Columbia University)

  • Robert A. Grassucci

    (Howard Hughes Medical Institute (HHMI), Columbia University)

  • Chandrajit Bajaj

    (Institute for Computational Engineering and Sciences, University of Texas)

  • Eric Westhof

    (Architecture et Réactivité de l’ARN, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire (CNRS))

  • Susan Madison-Antenucci

    (Wadsworth Center)

  • Joachim Frank

    (Howard Hughes Medical Institute (HHMI), Columbia University
    Columbia University
    Columbia University)

Abstract

High-resolution cryo-electron microscopy shows that the Trypanosoma brucei kinetoplastid ribosome is characterized by the presence of large expansion segments, ribosomal-protein extensions and additional rRNA insertions, which may have implications for the protein-translation regulation process.

Suggested Citation

  • Yaser Hashem & Amedee des Georges & Jie Fu & Sarah N. Buss & Fabrice Jossinet & Amy Jobe & Qin Zhang & Hstau Y. Liao & Robert A. Grassucci & Chandrajit Bajaj & Eric Westhof & Susan Madison-Antenucci &, 2013. "High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome," Nature, Nature, vol. 494(7437), pages 385-389, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7437:d:10.1038_nature11872
    DOI: 10.1038/nature11872
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    Cited by:

    1. Haonan Zhang & Yan Li & Yanan Liu & Dongyu Li & Lin Wang & Kai Song & Keyan Bao & Ping Zhu, 2023. "A method for restoring signals and revealing individual macromolecule states in cryo-ET, REST," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. K. Shanmugha Rajan & Hava Madmoni & Anat Bashan & Masato Taoka & Saurav Aryal & Yuko Nobe & Tirza Doniger & Beathrice Galili Kostin & Amit Blumberg & Smadar Cohen-Chalamish & Schraga Schwartz & Andre , 2023. "A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Florent Waltz & Thalia Salinas-Giegé & Robert Englmeier & Herrade Meichel & Heddy Soufari & Lauriane Kuhn & Stefan Pfeffer & Friedrich Förster & Benjamin D. Engel & Philippe Giegé & Laurence Drouard &, 2021. "How to build a ribosome from RNA fragments in Chlamydomonas mitochondria," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    4. Victor Tobiasson & Ieva Berzina & Alexey Amunts, 2022. "Structure of a mitochondrial ribosome with fragmented rRNA in complex with membrane-targeting elements," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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