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Genetic programs constructed from layered logic gates in single cells

Author

Listed:
  • Tae Seok Moon

    (Synthetic Biology Center, Massachusetts Institute of Technology
    Present address: Department of Energy, Environmental & Chemical Engineering, Washington University in St Louis, St Louis, Missouri 63130, USA.)

  • Chunbo Lou

    (Synthetic Biology Center, Massachusetts Institute of Technology)

  • Alvin Tamsir

    (Tetrad Graduate Program, University of California San Francisco)

  • Brynne C. Stanton

    (Synthetic Biology Center, Massachusetts Institute of Technology)

  • Christopher A. Voigt

    (Synthetic Biology Center, Massachusetts Institute of Technology)

Abstract

The creation of orthogonal ‘AND’ logic gates by combining DNA-binding proteins into complex, layered circuits opens the way to the design of programmable integrated circuits in synthetic biology.

Suggested Citation

  • Tae Seok Moon & Chunbo Lou & Alvin Tamsir & Brynne C. Stanton & Christopher A. Voigt, 2012. "Genetic programs constructed from layered logic gates in single cells," Nature, Nature, vol. 491(7423), pages 249-253, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7423:d:10.1038_nature11516
    DOI: 10.1038/nature11516
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    Citations

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    Cited by:

    1. Javier Macia & Romilde Manzoni & Núria Conde & Arturo Urrios & Eulàlia de Nadal & Ricard Solé & Francesc Posas, 2016. "Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia," PLOS Computational Biology, Public Library of Science, vol. 12(2), pages 1-24, February.
    2. Singh, Vijai & Chaudhary, Dharmendra Kumar & Mani, Indra & Dhar, Pawan Kumar, 2016. "Recent advances and challenges of the use of cyanobacteria towards the production of biofuels," Renewable and Sustainable Energy Reviews, Elsevier, vol. 60(C), pages 1-10.
    3. Judee A. Sharon & Chelsea Dasrath & Aiden Fujiwara & Alessandro Snyder & Mace Blank & Sam O’Brien & Lauren M. Aufdembrink & Aaron E. Engelhart & Katarzyna P. Adamala, 2023. "Trumpet is an operating system for simple and robust cell-free biocomputing," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Kanakov, Oleg & Chen, Shangbin & Zaikin, Alexey, 2024. "Learning by selective plasmid loss for intracellular synthetic classifiers," Chaos, Solitons & Fractals, Elsevier, vol. 179(C).
    5. Yuanli Gao & Lei Wang & Baojun Wang, 2023. "Customizing cellular signal processing by synthetic multi-level regulatory circuits," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Zomorrodi, Ali R. & Maranas, Costas D., 2014. "Coarse-grained optimization-driven design and piecewise linear modeling of synthetic genetic circuits," European Journal of Operational Research, Elsevier, vol. 237(2), pages 665-676.

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