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Reciprocal interactions of the intestinal microbiota and immune system

Author

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  • Craig L. Maynard

    (The University of Alabama at Birmingham)

  • Charles O. Elson

    (The University of Alabama at Birmingham)

  • Robin D. Hatton

    (The University of Alabama at Birmingham)

  • Casey T. Weaver

    (The University of Alabama at Birmingham)

Abstract

The emergence of the adaptive immune system in vertebrates set the stage for evolution of an advanced symbiotic relationship with the intestinal microbiota. The defining features of specificity and memory that characterize adaptive immunity have afforded vertebrates the mechanisms for efficiently tailoring immune responses to diverse types of microbes, whether to promote mutualism or host defence. These same attributes can put the host at risk of immune-mediated diseases that are increasingly linked to the intestinal microbiota. Understanding how the adaptive immune system copes with the remarkable number and diversity of microbes that colonize the digestive tract, and how the system integrates with more primitive innate immune mechanisms to maintain immune homeostasis, holds considerable promise for new approaches to modulate immune networks to treat and prevent disease.

Suggested Citation

  • Craig L. Maynard & Charles O. Elson & Robin D. Hatton & Casey T. Weaver, 2012. "Reciprocal interactions of the intestinal microbiota and immune system," Nature, Nature, vol. 489(7415), pages 231-241, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7415:d:10.1038_nature11551
    DOI: 10.1038/nature11551
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    Cited by:

    1. Jonathan Pelegrin-Valls & Javier Álvarez-Rodríguez & María José Martín-Alonso & Gustavo Adolfo Ramírez & Claudia Baila & Sandra Lobon & Margalida Joy & Beatriz Serrano-Pérez, 2022. "Effect of Maternal Dietary Condensed Tannins from Sainfoin ( Onobrychis viciifolia ) on Gut Health and Antioxidant-Immune Crosstalk in Suckling Lambs," Agriculture, MDPI, vol. 12(10), pages 1-13, October.
    2. Emidio Scarpellini & Emanuele Rinninella & Martina Basilico & Esther Colomier & Carlo Rasetti & Tiziana Larussa & Pierangelo Santori & Ludovico Abenavoli, 2021. "From Pre- and Probiotics to Post-Biotics: A Narrative Review," IJERPH, MDPI, vol. 19(1), pages 1-14, December.
    3. Monica Vera-Lise Tulstrup & Ellen Gerd Christensen & Vera Carvalho & Caroline Linninge & Siv Ahrné & Ole Højberg & Tine Rask Licht & Martin Iain Bahl, 2015. "Antibiotic Treatment Affects Intestinal Permeability and Gut Microbial Composition in Wistar Rats Dependent on Antibiotic Class," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-17, December.
    4. Lukas Schwingshackl & Georg Hoffmann & Carolina Schwedhelm & Tamara Kalle-Uhlmann & Benjamin Missbach & Sven Knüppel & Heiner Boeing, 2016. "Consumption of Dairy Products in Relation to Changes in Anthropometric Variables in Adult Populations: A Systematic Review and Meta-Analysis of Cohort Studies," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-15, June.

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