IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v487y2012i7406d10.1038_nature11125.html
   My bibliography  Save this article

The mutational landscape of lethal castration-resistant prostate cancer

Author

Listed:
  • Catherine S. Grasso

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Yi-Mi Wu

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Dan R. Robinson

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Xuhong Cao

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    Howard Hughes Medical Institute, University of Michigan Medical School)

  • Saravana M. Dhanasekaran

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Amjad P. Khan

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Michael J. Quist

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Xiaojun Jing

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Robert J. Lonigro

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School)

  • J. Chad Brenner

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Irfan A. Asangani

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Bushra Ateeq

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Sang Y. Chun

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Javed Siddiqui

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Lee Sam

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Matt Anstett

    (Compendia Bioscience)

  • Rohit Mehra

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • John R. Prensner

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Nallasivam Palanisamy

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School)

  • Gregory A. Ryslik

    (Yale School of Public Health)

  • Fabio Vandin

    (Brown University)

  • Benjamin J. Raphael

    (Brown University)

  • Lakshmi P. Kunju

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Daniel R. Rhodes

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School
    Compendia Bioscience)

  • Kenneth J. Pienta

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School
    University of Michigan Medical School
    University of Michigan Medical School)

  • Arul M. Chinnaiyan

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School
    Howard Hughes Medical Institute, University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School)

  • Scott A. Tomlins

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

Abstract

Exome sequencing is used to investigate the role of mutations and copy number aberrations in metastatic castration-resistant prostate cancer, revealing recurrent mutations in multiple chromatin/histone modifying genes, as well as genes involved in androgen signalling.

Suggested Citation

  • Catherine S. Grasso & Yi-Mi Wu & Dan R. Robinson & Xuhong Cao & Saravana M. Dhanasekaran & Amjad P. Khan & Michael J. Quist & Xiaojun Jing & Robert J. Lonigro & J. Chad Brenner & Irfan A. Asangani & B, 2012. "The mutational landscape of lethal castration-resistant prostate cancer," Nature, Nature, vol. 487(7406), pages 239-243, July.
  • Handle: RePEc:nat:nature:v:487:y:2012:i:7406:d:10.1038_nature11125
    DOI: 10.1038/nature11125
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11125
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature11125?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Chih-Wei Chou & Chia-Nung Hung & Cheryl Hsiang-Ling Chiu & Xi Tan & Meizhen Chen & Chien-Chin Chen & Moawiz Saeed & Che-Wei Hsu & Michael A. Liss & Chiou-Miin Wang & Zhao Lai & Nathaniel Alvarez & Paw, 2023. "Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Yiwu Yan & Bo Zhou & Chen Qian & Alex Vasquez & Mohini Kamra & Avradip Chatterjee & Yeon-Joo Lee & Xiaopu Yuan & Leigh Ellis & Dolores Vizio & Edwin M. Posadas & Natasha Kyprianou & Beatrice S. Knudse, 2022. "Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Xiaoguang Pan & Kunli Qu & Hao Yuan & Xi Xiang & Christian Anthon & Liubov Pashkova & Xue Liang & Peng Han & Giulia I. Corsi & Fengping Xu & Ping Liu & Jiayan Zhong & Yan Zhou & Tao Ma & Hui Jiang & J, 2022. "Massively targeted evaluation of therapeutic CRISPR off-targets in cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Chandrani Mukhopadhyay & Chenyi Yang & Limei Xu & Deli Liu & Yu Wang & Dennis Huang & Lesa Dayal Deonarine & Joanna Cyrta & Elai Davicioni & Andrea Sboner & Brian. D. Robinson & Arul M. Chinnaiyan & M, 2021. "G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    5. Jeroen Kneppers & Tesa M. Severson & Joseph C. Siefert & Pieter Schol & Stacey E. P. Joosten & Ivan Pak Lok Yu & Chia-Chi Flora Huang & Tunç Morova & Umut Berkay Altıntaş & Claudia Giambartolomei & Ji, 2022. "Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Sandra M. Rocha & Sílvia Socorro & Luís A. Passarinha & Cláudio J. Maia, 2022. "Comprehensive Landscape of STEAP Family Members Expression in Human Cancers: Unraveling the Potential Usefulness in Clinical Practice Using Integrated Bioinformatics Analysis," Data, MDPI, vol. 7(5), pages 1-48, May.
    7. Michael Fraser & Julie Livingstone & Jeffrey L. Wrana & Antonio Finelli & Housheng Hansen He & Theodorus van der Kwast & Alexandre R. Zlotta & Robert G. Bristow & Paul C. Boutros, 2021. "Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    8. Huiqiang Cai & Bin Zhang & Johanne Ahrenfeldt & Justin V. Joseph & Maria Riedel & Zongliang Gao & Sofie K. Thomsen & Ditte S. Christensen & Rasmus O. Bak & Henrik Hager & Mikkel H. Vendelbo & Xin Gao , 2024. "CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:487:y:2012:i:7406:d:10.1038_nature11125. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.