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The contribution of bone to whole-organism physiology

Author

Listed:
  • Gérard Karsenty

    (College of Physicians and Surgeons, Columbia University)

  • Mathieu Ferron

    (College of Physicians and Surgeons, Columbia University)

Abstract

The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.

Suggested Citation

  • Gérard Karsenty & Mathieu Ferron, 2012. "The contribution of bone to whole-organism physiology," Nature, Nature, vol. 481(7381), pages 314-320, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7381:d:10.1038_nature10763
    DOI: 10.1038/nature10763
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    Cited by:

    1. Sok Kuan Wong & Kok-Yong Chin & Farihah Hj Suhaimi & Fairus Ahmad & Soelaiman Ima-Nirwana, 2018. "The Effects of Vitamin E from Elaeis guineensis (Oil Palm) in a Rat Model of Bone Loss Due to Metabolic Syndrome," IJERPH, MDPI, vol. 15(9), pages 1-12, August.
    2. Jaromir Jarecki & Teresa Małecka-Masalska & Ewa Kosior-Jarecka & Wojciech Widuchowski & Piotr Krasowski & Martina Gutbier & Maciej Dobrzyński & Tomasz Blicharski, 2022. "Concentration of Selected Metalloproteinases and Osteocalcin in the Serum and Synovial Fluid of Obese Women with Advanced Knee Osteoarthritis," IJERPH, MDPI, vol. 19(6), pages 1-13, March.

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