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Concentration of Selected Metalloproteinases and Osteocalcin in the Serum and Synovial Fluid of Obese Women with Advanced Knee Osteoarthritis

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  • Jaromir Jarecki

    (Department of Rehabilitation and Orthopaedics, Medical University of Lublin, 20-059 Lublin, Poland
    Department of Orthopaedics and Traumatology, Regional Hospital in Chełm, 22-100 Chełm, Poland)

  • Teresa Małecka-Masalska

    (Physiology Department, Medical University of Lublin, 20-059 Lublin, Poland)

  • Ewa Kosior-Jarecka

    (Department Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, 20-079 Lublin, Poland)

  • Wojciech Widuchowski

    (Departament of Physiotherapy, The College of Physiotherapy, 50-038 Wrocław, Poland)

  • Piotr Krasowski

    (Department of Orthopaedics and Traumatology, Regional Hospital in Chełm, 22-100 Chełm, Poland)

  • Martina Gutbier

    (Department of Pediatric Dentistry and Preclinical Dentistry, Wrocław Medical University, Krakowska 26, 50-425 Wrocław, Poland)

  • Maciej Dobrzyński

    (Department of Pediatric Dentistry and Preclinical Dentistry, Wrocław Medical University, Krakowska 26, 50-425 Wrocław, Poland)

  • Tomasz Blicharski

    (Department of Rehabilitation and Orthopaedics, Medical University of Lublin, 20-059 Lublin, Poland)

Abstract

The aim of the study was to evaluate the levels of selected MMPs (matrix metalloproteinases) and osteocalcin in the serum and synovial fluid of obese women with osteoarthritis and their correlations with clinical status. The studied group consisted of 39 overweight females undergoing primary total knee arthroplasty due to osteoarthritis (OA). The staging of knee OA was evaluated according to the Ahlbӓck and Kellgren–Lawrence scores. Synovial fluid and peripheral blood samples were obtained. The levels of selected MMPs and osteocalcin were assessed using commercial ELISA kits. The mean value of MMP3 was significantly higher in patients with more advanced disease in both serum ( p = 0.0067) and synovial fluid ( p = 0.0328). The pro-MMP13 level tended to be higher in synovial fluid in the case of more advanced stages ( p = 0.0882), with no tendency regarding the serum level ( p = 0.9595). The synovial level of pro-MMP1 was significantly correlated with the synovial concentration of MMP9 and MMP3. The synovial level of MMP9 also showed a significant correlation with the synovial level of MMP3 and pro-MMP13. Furthermore, it was found that the serum level of MMP3 was significantly correlated with the synovial pro-MMP13 level. A correlation between the osteocalcin level in serum and its synovial level was determined. The serum MMP9 level showed a significant correlation with BMI, whereas the synovial MMP9 level was notably correlated with age. Our results showed that the levels of MMP3, MMP9, and pro-MMP13 increased in more advanced radiological stages of OA, indicating the underlying inflammatory process of OA.

Suggested Citation

  • Jaromir Jarecki & Teresa Małecka-Masalska & Ewa Kosior-Jarecka & Wojciech Widuchowski & Piotr Krasowski & Martina Gutbier & Maciej Dobrzyński & Tomasz Blicharski, 2022. "Concentration of Selected Metalloproteinases and Osteocalcin in the Serum and Synovial Fluid of Obese Women with Advanced Knee Osteoarthritis," IJERPH, MDPI, vol. 19(6), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3530-:d:772541
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    References listed on IDEAS

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    1. Gérard Karsenty & Mathieu Ferron, 2012. "The contribution of bone to whole-organism physiology," Nature, Nature, vol. 481(7381), pages 314-320, January.
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