IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v480y2011i7378d10.1038_nature10648.html
   My bibliography  Save this article

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

Author

Listed:
  • Sonja Kriks

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Jae-Won Shim

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Jinghua Piao

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Yosif M. Ganat

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Dustin R. Wakeman

    (Rush University Medical Center)

  • Zhong Xie

    (Feinberg School of Medicine, Northwestern University)

  • Luis Carrillo-Reid

    (Feinberg School of Medicine, Northwestern University)

  • Gordon Auyeung

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Chris Antonacci

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Amanda Buch

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Lichuan Yang

    (Weill Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, New York 10021, USA)

  • M. Flint Beal

    (Weill Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, New York 10021, USA)

  • D. James Surmeier

    (Feinberg School of Medicine, Northwestern University)

  • Jeffrey H. Kordower

    (Rush University Medical Center)

  • Viviane Tabar

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Lorenz Studer

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

Abstract

A new strategy for derivation of human midbrain dopamine neurons from pluripotent cells was developed; transplantation of the neurons in mice, rats and parkinsonian monkeys show they are a promising source of cells for applications in regenerative medicine.

Suggested Citation

  • Sonja Kriks & Jae-Won Shim & Jinghua Piao & Yosif M. Ganat & Dustin R. Wakeman & Zhong Xie & Luis Carrillo-Reid & Gordon Auyeung & Chris Antonacci & Amanda Buch & Lichuan Yang & M. Flint Beal & D. Jam, 2011. "Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease," Nature, Nature, vol. 480(7378), pages 547-551, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7378:d:10.1038_nature10648
    DOI: 10.1038/nature10648
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10648
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10648?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kimberly C. Paul & Richard C. Krolewski & Edinson Lucumi Moreno & Jack Blank & Kristina M. Holton & Tim Ahfeldt & Melissa Furlong & Yu Yu & Myles Cockburn & Laura K. Thompson & Alexander Kreymerman & , 2023. "A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Willayat Y. Wani & Friederike Zunke & Nandkishore R. Belur & Joseph R. Mazzulli, 2024. "The hexosamine biosynthetic pathway rescues lysosomal dysfunction in Parkinson’s disease patient iPSC derived midbrain neurons," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Gustavo Morrone Parfitt & Elena Coccia & Camille Goldman & Kristen Whitney & Ricardo Reyes & Lily Sarrafha & Ki Hong Nam & Soha Sohail & Drew R. Jones & John F. Crary & Alban Ordureau & Joel Blanchard, 2024. "Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease model," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Juliane Tschuck & Vidya Padmanabhan Nair & Ana Galhoz & Carole Zaratiegui & Hin-Man Tai & Gabriele Ciceri & Ina Rothenaigner & Jason Tchieu & Brent R. Stockwell & Lorenz Studer & Daphne S. Cabianca & , 2024. "Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. A. de Rus Jacquet & M. Alpaugh & H. L. Denis & J. L. Tancredi & M. Boutin & J. Decaestecker & C. Beauparlant & L. Herrmann & M. Saint-Pierre & M. Parent & A. Droit & S. Breton & F. Cicchetti, 2023. "The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson’s disease," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    6. Zhanna Alekseenko & José M. Dias & Andrew F. Adler & Mariya Kozhevnikova & Josina Anna Lunteren & Sara Nolbrant & Ashwini Jeggari & Svitlana Vasylovska & Takashi Yoshitake & Jan Kehr & Marie Carlén & , 2022. "Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:480:y:2011:i:7378:d:10.1038_nature10648. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.