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Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

Author

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  • Sonja Kriks

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Jae-Won Shim

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Jinghua Piao

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Yosif M. Ganat

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Dustin R. Wakeman

    (Rush University Medical Center)

  • Zhong Xie

    (Feinberg School of Medicine, Northwestern University)

  • Luis Carrillo-Reid

    (Feinberg School of Medicine, Northwestern University)

  • Gordon Auyeung

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Chris Antonacci

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Amanda Buch

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Lichuan Yang

    (Weill Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, New York 10021, USA)

  • M. Flint Beal

    (Weill Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, New York 10021, USA)

  • D. James Surmeier

    (Feinberg School of Medicine, Northwestern University)

  • Jeffrey H. Kordower

    (Rush University Medical Center)

  • Viviane Tabar

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Lorenz Studer

    (Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

Abstract

A new strategy for derivation of human midbrain dopamine neurons from pluripotent cells was developed; transplantation of the neurons in mice, rats and parkinsonian monkeys show they are a promising source of cells for applications in regenerative medicine.

Suggested Citation

  • Sonja Kriks & Jae-Won Shim & Jinghua Piao & Yosif M. Ganat & Dustin R. Wakeman & Zhong Xie & Luis Carrillo-Reid & Gordon Auyeung & Chris Antonacci & Amanda Buch & Lichuan Yang & M. Flint Beal & D. Jam, 2011. "Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease," Nature, Nature, vol. 480(7378), pages 547-551, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7378:d:10.1038_nature10648
    DOI: 10.1038/nature10648
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    Citations

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    Cited by:

    1. Willayat Y. Wani & Friederike Zunke & Nandkishore R. Belur & Joseph R. Mazzulli, 2024. "The hexosamine biosynthetic pathway rescues lysosomal dysfunction in Parkinson’s disease patient iPSC derived midbrain neurons," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Gustavo Morrone Parfitt & Elena Coccia & Camille Goldman & Kristen Whitney & Ricardo Reyes & Lily Sarrafha & Ki Hong Nam & Soha Sohail & Drew R. Jones & John F. Crary & Alban Ordureau & Joel Blanchard, 2024. "Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease model," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Juliane Tschuck & Vidya Padmanabhan Nair & Ana Galhoz & Carole Zaratiegui & Hin-Man Tai & Gabriele Ciceri & Ina Rothenaigner & Jason Tchieu & Brent R. Stockwell & Lorenz Studer & Daphne S. Cabianca & , 2024. "Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Kimberly C. Paul & Richard C. Krolewski & Edinson Lucumi Moreno & Jack Blank & Kristina M. Holton & Tim Ahfeldt & Melissa Furlong & Yu Yu & Myles Cockburn & Laura K. Thompson & Alexander Kreymerman & , 2023. "A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    5. A. de Rus Jacquet & M. Alpaugh & H. L. Denis & J. L. Tancredi & M. Boutin & J. Decaestecker & C. Beauparlant & L. Herrmann & M. Saint-Pierre & M. Parent & A. Droit & S. Breton & F. Cicchetti, 2023. "The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson’s disease," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    6. Zhanna Alekseenko & José M. Dias & Andrew F. Adler & Mariya Kozhevnikova & Josina Anna Lunteren & Sara Nolbrant & Ashwini Jeggari & Svitlana Vasylovska & Takashi Yoshitake & Jan Kehr & Marie Carlén & , 2022. "Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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