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Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

Author

Listed:
  • Alex Sigal

    (California Institute of Technology)

  • Jocelyn T. Kim

    (California Institute of Technology
    David Geffen School of Medicine at UCLA)

  • Alejandro B. Balazs

    (California Institute of Technology)

  • Erez Dekel

    (Weizmann Institute of Science)

  • Avi Mayo

    (Weizmann Institute of Science)

  • Ron Milo

    (Weizmann Institute of Science)

  • David Baltimore

    (California Institute of Technology)

Abstract

HIV persists through continued transmission Antiretroviral therapy suppresses, but does not eradicate, HIV infection. Low-level viraemia continues for life because of the persistence of treatment-resistant reservoirs of the virus. Various different types of reservoir are thought to exist. David Baltimore and colleagues use a combination of mathematical modelling and a cell culture model of HIV infection and drug treatment to propose that ongoing HIV replication can occur in the presence of drugs if the cells become infected through cell-to-cell transmission. They propose that cell-to-cell spread of virus could be a source of localized and intermittent ongoing replication, which may show little evolution, and which could contribute to replenishment of the virus reservoir and virus persistence.

Suggested Citation

  • Alex Sigal & Jocelyn T. Kim & Alejandro B. Balazs & Erez Dekel & Avi Mayo & Ron Milo & David Baltimore, 2011. "Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy," Nature, Nature, vol. 477(7362), pages 95-98, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7362:d:10.1038_nature10347
    DOI: 10.1038/nature10347
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    Cited by:

    1. Chen, Chong & Zhou, Yinggao, 2023. "Dynamic analysis of HIV model with a general incidence, CTLs immune response and intracellular delays," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 212(C), pages 159-181.
    2. Noura H. AlShamrani & Reham H. Halawani & Ahmed M. Elaiw, 2023. "Effect of Impaired B-Cell and CTL Functions on HIV-1 Dynamics," Mathematics, MDPI, vol. 11(20), pages 1-39, October.
    3. Noura H. AlShamrani & Ahmed Elaiw & Aeshah A. Raezah & Khalid Hattaf, 2023. "Global Dynamics of a Diffusive Within-Host HTLV/HIV Co-Infection Model with Latency," Mathematics, MDPI, vol. 11(6), pages 1-47, March.
    4. Wang, Yan & Qi, Kai & Jiang, Daqing, 2021. "An HIV latent infection model with cell-to-cell transmission and stochastic perturbation," Chaos, Solitons & Fractals, Elsevier, vol. 151(C).
    5. AlShamrani, N.H., 2021. "Stability of a general adaptive immunity HIV infection model with silent infected cell-to-cell spread," Chaos, Solitons & Fractals, Elsevier, vol. 150(C).
    6. Lucia Reh & Carsten Magnus & Merle Schanz & Jacqueline Weber & Therese Uhr & Peter Rusert & Alexandra Trkola, 2015. "Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent," PLOS Pathogens, Public Library of Science, vol. 11(7), pages 1-34, July.
    7. Attaullah, & Jan, Rashid & Yüzbaşı, Şuayip, 2021. "Dynamical behaviour of HIV Infection with the influence of variable source term through Galerkin method," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).
    8. Pinto, Carla M.A. & Carvalho, Ana R.M., 2017. "The role of synaptic transmission in a HIV model with memory," Applied Mathematics and Computation, Elsevier, vol. 292(C), pages 76-95.
    9. Mojaver, Aida & Kheiri, Hossein, 2015. "Mathematical analysis of a class of HIV infection models of CD4+ T-cells with combined antiretroviral therapy," Applied Mathematics and Computation, Elsevier, vol. 259(C), pages 258-270.
    10. Ma, Yuanlin & Yu, Xingwang, 2020. "The effect of environmental noise on threshold dynamics for a stochastic viral infection model with two modes of transmission and immune impairment," Chaos, Solitons & Fractals, Elsevier, vol. 134(C).
    11. Liu, Lili & Ma, Xiaomin & Li, Yazhi & Liu, Xianning, 2023. "Mathematical analysis of global dynamics and optimal control of treatment for an age-structured HBV infection model," Chaos, Solitons & Fractals, Elsevier, vol. 177(C).
    12. Lin, Jiazhe & Xu, Rui & Tian, Xiaohong, 2017. "Threshold dynamics of an HIV-1 virus model with both virus-to-cell and cell-to-cell transmissions, intracellular delay, and humoral immunity," Applied Mathematics and Computation, Elsevier, vol. 315(C), pages 516-530.
    13. Günerhan, Hatıra & Dutta, Hemen & Dokuyucu, Mustafa Ali & Adel, Waleed, 2020. "Analysis of a fractional HIV model with Caputo and constant proportional Caputo operators," Chaos, Solitons & Fractals, Elsevier, vol. 139(C).

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