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The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations

Author

Listed:
  • T. Walker

    (School of Biological Sciences, The University of Queensland)

  • P. H. Johnson

    (School of Public Health and Tropical Medicine and Rehabilitative Sciences, James Cook University)

  • L. A. Moreira

    (School of Biological Sciences, The University of Queensland
    Present addresses: Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, MG 30190, Brasil (L.A.M.); Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, Campus Box 63, New York, New York10065, USA (C.J.M.).)

  • I. Iturbe-Ormaetxe

    (School of Biological Sciences, The University of Queensland)

  • F. D. Frentiu

    (School of Biological Sciences, The University of Queensland)

  • C. J. McMeniman

    (School of Biological Sciences, The University of Queensland
    Present addresses: Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, MG 30190, Brasil (L.A.M.); Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, Campus Box 63, New York, New York10065, USA (C.J.M.).)

  • Y. S. Leong

    (School of Biological Sciences, The University of Queensland)

  • Y. Dong

    (School of Biological Sciences, The University of Queensland)

  • J. Axford

    (Bio21 Institute, The University of Melbourne, Victoria 3010, Australia)

  • P. Kriesner

    (Bio21 Institute, The University of Melbourne, Victoria 3010, Australia)

  • A. L. Lloyd

    (North Carolina State University
    Fogarty International Center, National Institutes of Health)

  • S. A. Ritchie

    (School of Public Health and Tropical Medicine and Rehabilitative Sciences, James Cook University)

  • S. L. O’Neill

    (School of Biological Sciences, The University of Queensland
    School of Biological Sciences, Monash University, Victoria 3800, Australia)

  • A. A. Hoffmann

    (Bio21 Institute, The University of Melbourne, Victoria 3010, Australia)

Abstract

Wolbachia used to counter dengue fever The mosquito-borne viral disease dengue fever is an increasing problem in tropical and subtropical regions. Traditional control measures aimed at reducing populations of the main transmission vector, Aedes aegypti, have had little success. Two papers in this issue report an alternative approach to mosquito population control using the bacterium Wolbachia pipientis, natural insect symbionts that facilitate their own transmission through a process called cytoplasmic incompatibility. In the first paper, Scott O'Neill and colleagues describe a Wolbachia strain derived from fruitflies that significantly reduces dengue virus carriage in mosquitoes without imposing a fitness cost. In the second paper, they demonstrate in a controlled field trial that the release of colonized mosquitoes leads to successful invasion of natural mosquito populations. These results suggest a viable strategy to control dengue fever.

Suggested Citation

  • T. Walker & P. H. Johnson & L. A. Moreira & I. Iturbe-Ormaetxe & F. D. Frentiu & C. J. McMeniman & Y. S. Leong & Y. Dong & J. Axford & P. Kriesner & A. L. Lloyd & S. A. Ritchie & S. L. O’Neill & A. A., 2011. "The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations," Nature, Nature, vol. 476(7361), pages 450-453, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7361:d:10.1038_nature10355
    DOI: 10.1038/nature10355
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    Cited by:

    1. Kalin M. Skinner & Jacob Underwood & Arnab Ghosh & Adela S. Oliva Chavez & Corey L. Brelsfoard, 2022. "Wolbachia Impacts Anaplasma Infection in Ixodes scapularis Tick Cells," IJERPH, MDPI, vol. 19(3), pages 1-9, January.
    2. Qiming Huang & Lijie Chang & Zhaowang Zhang & Bo Zheng, 2023. "Global Dynamics for Competition between Two Wolbachia Strains with Bidirectional Cytoplasmic Incompatibility," Mathematics, MDPI, vol. 11(7), pages 1-21, April.
    3. Turelli, Michael & Barton, Nicholas H., 2017. "Deploying dengue-suppressing Wolbachia : Robust models predict slow but effective spatial spread in Aedes aegypti," Theoretical Population Biology, Elsevier, vol. 115(C), pages 45-60.
    4. Li, Yazhi & Wang, Yan & Liu, Lili, 2023. "Optimal control of dengue vector based on a reaction–diffusion model," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 203(C), pages 250-270.
    5. Vanessa M. Macias & Johanna R. Ohm & Jason L. Rasgon, 2017. "Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?," IJERPH, MDPI, vol. 14(9), pages 1-30, September.
    6. Auliya A. Suwantika & Angga P. Kautsar & Woro Supadmi & Neily Zakiyah & Rizky Abdulah & Mohammad Ali & Maarten J. Postma, 2020. "Cost-Effectiveness of Dengue Vaccination in Indonesia: Considering Integrated Programs with Wolbachia -Infected Mosquitos and Health Education," IJERPH, MDPI, vol. 17(12), pages 1-15, June.
    7. Kristina K. Gonzales & Immo A. Hansen, 2016. "Artificial Diets for Mosquitoes," IJERPH, MDPI, vol. 13(12), pages 1-13, December.
    8. Lijie Chang & Yantao Shi & Bo Zheng, 2021. "Existence and Uniqueness of Nontrivial Periodic Solutions to a Discrete Switching Model," Mathematics, MDPI, vol. 9(19), pages 1-13, September.
    9. Meksianis Z. Ndii & Lazarus Kalvein Beay & Nursanti Anggriani & Karolina N. Nukul & Bertha S. Djahi, 2022. "Estimating the Time Reproduction Number in Kupang City Indonesia, 2016–2020, and Assessing the Effects of Vaccination and Different Wolbachia Strains on Dengue Transmission Dynamics," Mathematics, MDPI, vol. 10(12), pages 1-18, June.
    10. Tiago França Melo De Lima & Raquel Martins Lana & Tiago Garcia De Senna Carneiro & Cláudia Torres Codeço & Gabriel Souza Machado & Lucas Saraiva Ferreira & Líliam César De Castro Medeiros & Clodoveu A, 2016. "DengueME: A Tool for the Modeling and Simulation of Dengue Spatiotemporal Dynamics," IJERPH, MDPI, vol. 13(9), pages 1-21, September.
    11. Xingtong Liu & Yuanshun Tan & Bo Zheng, 2022. "Dynamic Behavior of an Interactive Mosquito Model under Stochastic Interference," Mathematics, MDPI, vol. 10(13), pages 1-18, June.
    12. Dianavinnarasi, J. & Raja, R. & Alzabut, J. & Cao, J. & Niezabitowski, M. & Bagdasar, O., 2022. "Application of Caputo–Fabrizio operator to suppress the Aedes Aegypti mosquitoes via Wolbachia: An LMI approach," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 201(C), pages 462-485.

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