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Polar actomyosin contractility destabilizes the position of the cytokinetic furrow

Author

Listed:
  • Jakub Sedzinski

    (Max Planck Institute of Molecular Cell Biology and Genetics
    International Institute of Molecular and Cell Biology)

  • Maté Biro

    (Max Planck Institute of Molecular Cell Biology and Genetics
    International Institute of Molecular and Cell Biology)

  • Annelie Oswald

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Jean-Yves Tinevez

    (Max Planck Institute of Molecular Cell Biology and Genetics
    International Institute of Molecular and Cell Biology
    Present address: Pasteur Institute, 75724 Paris, France.)

  • Guillaume Salbreux

    (Max Planck Institute for the Physics of Complex Systems)

  • Ewa Paluch

    (Max Planck Institute of Molecular Cell Biology and Genetics
    International Institute of Molecular and Cell Biology)

Abstract

How dividing cells stay in shape Studies of the mechanism of cytokinesis, the process by which a mother cell undergoes cleavage to form two separated daughter cells, often focus on the action of the contractile actomyosin ring at the cell equator. Ewa Paluch and colleagues instead investigate the mechanics of the actomyosin cortex found at the cell poles during cytokinesis. They find that the presence of a contractile polar cortex makes cytokinesis an inherently unstable process that can result in misalignment of the constriction ring. They propose that the membrane blebs forming at the poles of dividing cells stabilize the position by releasing cortical contractility. These findings reveal an inherent instability in the shape of a dividing cell and demonstrate a novel mechanism that helps to limit shape instability.

Suggested Citation

  • Jakub Sedzinski & Maté Biro & Annelie Oswald & Jean-Yves Tinevez & Guillaume Salbreux & Ewa Paluch, 2011. "Polar actomyosin contractility destabilizes the position of the cytokinetic furrow," Nature, Nature, vol. 476(7361), pages 462-466, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7361:d:10.1038_nature10286
    DOI: 10.1038/nature10286
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    Cited by:

    1. Emilie Montembault & Irène Deduyer & Marie-Charlotte Claverie & Lou Bouit & Nicolas J. Tourasse & Denis Dupuy & Derek McCusker & Anne Royou, 2023. "Two RhoGEF isoforms with distinct localisation control furrow position during asymmetric cell division," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Kei Yamamoto & Haruko Miura & Motohiko Ishida & Yusuke Mii & Noriyuki Kinoshita & Shinji Takada & Naoto Ueno & Satoshi Sawai & Yohei Kondo & Kazuhiro Aoki, 2021. "Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Ryota Sakamoto & Michael P. Murrell, 2024. "Mechanical power is maximized during contractile ring-like formation in a biomimetic dividing cell model," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Francesca Mateo & Zhengcheng He & Lin Mei & Gorka Ruiz de Garibay & Carmen Herranz & Nadia García & Amanda Lorentzian & Alexandra Baiges & Eline Blommaert & Antonio Gómez & Oriol Mirallas & Anna Garri, 2022. "Modification of BRCA1-associated breast cancer risk by HMMR overexpression," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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