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Type VI secretion delivers bacteriolytic effectors to target cells

Author

Listed:
  • Alistair B. Russell

    (University of Washington)

  • Rachel D. Hood

    (University of Washington)

  • Nhat Khai Bui

    (Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK)

  • Michele LeRoux

    (Molecular and Cellular Biology Program, University of Washington)

  • Waldemar Vollmer

    (Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK)

  • Joseph D. Mougous

    (University of Washington)

Abstract

Peptidoglycan is the major structural constituent of the bacterial cell wall, forming a meshwork outside the cytoplasmic membrane that maintains cell shape and prevents lysis. In Gram-negative bacteria, peptidoglycan is located in the periplasm, where it is protected from exogenous lytic enzymes by the outer membrane. Here we show that the type VI secretion system of Pseudomonas aeruginosa breaches this barrier to deliver two effector proteins, Tse1 and Tse3, to the periplasm of recipient cells. In this compartment, the effectors hydrolyse peptidoglycan, thereby providing a fitness advantage for P. aeruginosa cells in competition with other bacteria. To protect itself from lysis by Tse1 and Tse3, P. aeruginosa uses specific periplasmically localized immunity proteins. The requirement for these immunity proteins depends on intercellular self-intoxication through an active type VI secretion system, indicating a mechanism for export whereby effectors do not access donor cell periplasm in transit.

Suggested Citation

  • Alistair B. Russell & Rachel D. Hood & Nhat Khai Bui & Michele LeRoux & Waldemar Vollmer & Joseph D. Mougous, 2011. "Type VI secretion delivers bacteriolytic effectors to target cells," Nature, Nature, vol. 475(7356), pages 343-347, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7356:d:10.1038_nature10244
    DOI: 10.1038/nature10244
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    Cited by:

    1. Massimiliano Marazzato & Daniela Scribano & Meysam Sarshar & Francesca Brunetti & Silvia Fillo & Antonella Fortunato & Florigio Lista & Anna Teresa Palamara & Carlo Zagaglia & Cecilia Ambrosi, 2022. "Genetic Diversity of Antimicrobial Resistance and Key Virulence Features in Two Extensively Drug-Resistant Acinetobacter baumannii Isolates," IJERPH, MDPI, vol. 19(5), pages 1-14, March.
    2. Toshiki Nagakubo & Tatsuya Nishiyama & Tatsuya Yamamoto & Nobuhiko Nomura & Masanori Toyofuku, 2024. "Contractile injection systems facilitate sporogenic differentiation of Streptomyces davawensis through the action of a phage tapemeasure protein-related effector," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Amaia González-Magaña & Igor Tascón & Jon Altuna-Alvarez & María Queralt-Martín & Jake Colautti & Carmen Velázquez & Maialen Zabala & Jessica Rojas-Palomino & Marité Cárdenas & Antonio Alcaraz & John , 2023. "Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Dandan Wang & Lingfang Zhu & Xiangkai Zhen & Daoyan Yang & Changfu Li & Yating Chen & Huannan Wang & Yichen Qu & Xiaozhen Liu & Yanling Yin & Huawei Gu & Lei Xu & Chuanxing Wan & Yao Wang & Songying O, 2022. "A secreted effector with a dual role as a toxin and as a transcriptional factor," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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