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Progress and challenges in translating the biology of atherosclerosis

Author

Listed:
  • Peter Libby

    (Brigham and Women's Hospital, Harvard Medical School)

  • Paul M Ridker

    (Brigham and Women's Hospital, Harvard Medical School
    Brigham and Women's Hospital, Harvard Medical School)

  • Göran K. Hansson

    (Karolinska University Hospital, Karolinska Institutet)

Abstract

Atherosclerosis is a chronic disease of the arterial wall, and a leading cause of death and loss of productive life years worldwide. Research into the disease has led to many compelling hypotheses about the pathophysiology of atherosclerotic lesion formation and of complications such as myocardial infarction and stroke. Yet, despite these advances, we still lack definitive evidence to show that processes such as lipoprotein oxidation, inflammation and immunity have a crucial involvement in human atherosclerosis. Experimental atherosclerosis in animals furnishes an important research tool, but extrapolation to humans requires care. Understanding how to combine experimental and clinical science will provide further insight into atherosclerosis and could lead to new clinical applications.

Suggested Citation

  • Peter Libby & Paul M Ridker & Göran K. Hansson, 2011. "Progress and challenges in translating the biology of atherosclerosis," Nature, Nature, vol. 473(7347), pages 317-325, May.
    • Handle: RePEc:nat:nature:v:473:y:2011:i:7347:d:10.1038_nature10146
    DOI: 10.1038/nature10146
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    2. Abderrahim Nemmar & Deepa Subramaniyan & Badreldin H Ali, 2012. "Protective Effect of Curcumin on Pulmonary and Cardiovascular Effects Induced by Repeated Exposure to Diesel Exhaust Particles in Mice," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-9, June.
    3. Mengying Wang & Siyue Wang & Xiaowen Wang & Junhui Wu & Yao Wu & Zijing Wang & Jiating Wang & Tao Wu & Yonghua Hu, 2020. "Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China," IJERPH, MDPI, vol. 18(1), pages 1-11, December.
    4. Stephanie D. Ansley & Jeffrey T. Howard, 2021. "Dietary Intake and Elevated C-Reactive Protein Levels in US Military Veterans," IJERPH, MDPI, vol. 18(2), pages 1-15, January.
    5. Todd, Megan A. & Shkolnikov, Vladimir M. & Goldman, Noreen, 2016. "Why are well-educated Muscovites more likely to survive? Understanding the biological pathways," Social Science & Medicine, Elsevier, vol. 157(C), pages 138-147.
    6. Timothy R Braun & Latonya F Been & Akhil Singhal & Jacob Worsham & Sarju Ralhan & Gurpreet S Wander & John C Chambers & Jaspal S Kooner & Christopher E Aston & Dharambir K Sanghera, 2012. "A Replication Study of GWAS-Derived Lipid Genes in Asian Indians: The Chromosomal Region 11q23.3 Harbors Loci Contributing to Triglycerides," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-12, May.
    7. Zeinab Emruzi & Ghasem Ahangari & Pegah Babaheidarian & Mahmoud Arshad, 2018. "Effect of Hyperlipidemia on Cell Mediated Immunity; Could it be as Predisposing Factor of Cancer Risk?," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 12(1), pages 8968-8973, December.
    8. Yusuke Adachi & Kazutaka Ueda & Seitaro Nomura & Kaoru Ito & Manami Katoh & Mikako Katagiri & Shintaro Yamada & Masaki Hashimoto & Bowen Zhai & Genri Numata & Akira Otani & Munetoshi Hinata & Yuta Hir, 2022. "Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    9. Patricia Hernández-López & Miguel A. Martínez & Estefanía Peña & Myriam Cilla, 2023. "Understanding the Parameter Influence on Lesion Growth for a Mechanobiology Model of Atherosclerosis," Mathematics, MDPI, vol. 11(4), pages 1-25, February.
    10. Tae Kyeong Kim & Sejin Jeon & Seonjun Park & Seong-Keun Sonn & Seungwoon Seo & Joowon Suh & Jing Jin & Hyae Yon Kweon & Sinai Kim & Shin Hye Moon & Okhee Kweon & Bon-Hyeock Koo & Nayoung Kim & Hae-Ock, 2022. "2′–5′ oligoadenylate synthetase‑like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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