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Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India

Author

Listed:
  • Ramadass Balamurugan

    (Wellcome Research Unit (Biochemistry), Christian Medical College, Vellore, Tamil Nadu 632004, India
    Current address: Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Bhubaneshwar, Odisha 751019, India.)

  • Srinivasan Pugazhendhi

    (Wellcome Research Unit (Biochemistry), Christian Medical College, Vellore, Tamil Nadu 632004, India)

  • Gowri M. Balachander

    (Wellcome Research Unit (Biochemistry), Christian Medical College, Vellore, Tamil Nadu 632004, India
    Current address: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore, Singapore.)

  • Tamilselvan Dharmalingam

    (Wellcome Research Unit (Biochemistry), Christian Medical College, Vellore, Tamil Nadu 632004, India)

  • Elissa K Mortimer

    (College of Medicine and Public Health, Flinders University of South Australia, Bedford Park 5045, South Australia, Australia)

  • Geetha L. Gopalsamy

    (College of Medicine and Public Health, Flinders University of South Australia, Bedford Park 5045, South Australia, Australia)

  • Richard J. Woodman

    (College of Medicine and Public Health, Flinders University of South Australia, Bedford Park 5045, South Australia, Australia)

  • Rosie Meng

    (College of Medicine and Public Health, Flinders University of South Australia, Bedford Park 5045, South Australia, Australia)

  • David H. Alpers

    (Washington University School of Medicine, Saint Louis, MO 63110, USA)

  • Mark Manary

    (Washington University School of Medicine, Saint Louis, MO 63110, USA)

  • Henry J. Binder

    (Yale University School of Medicine, New Haven, CT 06510, USA)

  • Ian L. Brown

    (Australian Cancer Research Foundation, Sydney 2000, Australia)

  • Graeme P. Young

    (College of Medicine and Public Health, Flinders University of South Australia, Bedford Park 5045, South Australia, Australia)

  • Balakrishnan S. Ramakrishna

    (Department of Gastroenterology, Christian Medical College, Vellore, Tamil Nadu 632004, India
    Current address: Institute of Gastroenterology, SRM Institutes for Medical Science, Chennai, Tamil Nadu 600026, India.)

Abstract

The health benefits of dietary amylase resistant starch (RS) arise from intestinal microbial fermentation and generation of short chain fatty acids (SCFA). We compared the intestinal fermentative capability of stunted and nonstunted (‘healthy’) children in southern India using two types of RS: high amylose maize starch (HAMS) and acetylated HAMS (HAMSA). Twenty children (10 stunted and 10 healthy) aged 2 to 5 years were fed biscuits containing HAMS (10 g/day) for two weeks followed by a 2-week washout and then HAMSA biscuits (10 g/day) for 2 weeks. Fecal samples were collected at 3-4 day intervals and pH and SCFA analyzed. At entry, stunted children had lower SCFA concentrations compared to healthy children. Both types of RS led to a significant decrease in fecal pH and increase in fecal acetate and propionate in both healthy and stunted children. However, while HAMS increased fecal butyrate in both groups of children, HAMSA increased butyrate in healthy but not stunted children. Furthermore, healthy children showed a significantly greater increase than stunted children in both acetate and butyrate when fed either RS. No adverse effects were reported with either RS. Stunted children have impaired capacity to ferment certain types of RS which has implications for choice of RS in formulations aimed at improving microbial function in stunted children.

Suggested Citation

  • Ramadass Balamurugan & Srinivasan Pugazhendhi & Gowri M. Balachander & Tamilselvan Dharmalingam & Elissa K Mortimer & Geetha L. Gopalsamy & Richard J. Woodman & Rosie Meng & David H. Alpers & Mark Man, 2019. "Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India," IJERPH, MDPI, vol. 16(20), pages 1-12, October.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:20:p:3922-:d:276833
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    References listed on IDEAS

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    1. Shinji Fukuda & Hidehiro Toh & Koji Hase & Kenshiro Oshima & Yumiko Nakanishi & Kazutoshi Yoshimura & Toru Tobe & Julie M. Clarke & David L. Topping & Tohru Suzuki & Todd D. Taylor & Kikuji Itoh & Jun, 2011. "Bifidobacteria can protect from enteropathogenic infection through production of acetate," Nature, Nature, vol. 469(7331), pages 543-547, January.
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