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Pericytes regulate the blood–brain barrier

Author

Listed:
  • Annika Armulik

    (Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden)

  • Guillem Genové

    (Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden)

  • Maarja Mäe

    (Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden)

  • Maya H. Nisancioglu

    (Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden)

  • Elisabet Wallgard

    (Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden
    Present addresses: Department of Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjölds väg 20, Uppsala University, SE-751 85 Uppsala, Sweden (E.W.); Applied Biosystems Sweden, Lindhagensgatan 76, PO Box 12650, SE-112 92 Stockholm, Sweden (L.H.); German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (K.S.).)

  • Colin Niaudet

    (Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden)

  • Liqun He

    (Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden
    Present addresses: Department of Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjölds väg 20, Uppsala University, SE-751 85 Uppsala, Sweden (E.W.); Applied Biosystems Sweden, Lindhagensgatan 76, PO Box 12650, SE-112 92 Stockholm, Sweden (L.H.); German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (K.S.).)

  • Jenny Norlin

    (Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden)

  • Per Lindblom

    (AstraZeneca AB, Clinical Development, SE-431 83 Mölndal, Sweden)

  • Karin Strittmatter

    (Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden
    Present addresses: Department of Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjölds väg 20, Uppsala University, SE-751 85 Uppsala, Sweden (E.W.); Applied Biosystems Sweden, Lindhagensgatan 76, PO Box 12650, SE-112 92 Stockholm, Sweden (L.H.); German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (K.S.).)

  • Bengt R. Johansson

    (The Electron Microscopy Unit, Institute for Biomedicine, The Sahlgrenska Academy, University of Gothenburg, PO Box 420, SE-405 30 Gothenburg, Sweden)

  • Christer Betsholtz

    (Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden)

Abstract

Building the blood–brain barrier The blood–brain barrier is a gatekeeper between the central nervous system and the rest of the body, and is made up of vascular endothelial cells. Previous work upheld the notion that the barrier was formed postnatally as a result of signalling from non-neuronal cells called astrocytes to endothelial cells. Now, two independent studies demonstrate that the barrier is in fact formed during embryogenesis, with the critical factor being the interaction between blood-vessel-surrounding cells called pericytes and epithelial cells. A better understanding of the tight relationship between pericytes, neuroendothelial cells and astrocytes in blood–brain barrier function will contribute to our understanding of the breakdown of the barrier during central nervous system injury and disease.

Suggested Citation

  • Annika Armulik & Guillem Genové & Maarja Mäe & Maya H. Nisancioglu & Elisabet Wallgard & Colin Niaudet & Liqun He & Jenny Norlin & Per Lindblom & Karin Strittmatter & Bengt R. Johansson & Christer Bet, 2010. "Pericytes regulate the blood–brain barrier," Nature, Nature, vol. 468(7323), pages 557-561, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7323:d:10.1038_nature09522
    DOI: 10.1038/nature09522
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    Cited by:

    1. Airi Jo-Watanabe & Toshiki Inaba & Takahiro Osada & Ryota Hashimoto & Tomohiro Nishizawa & Toshiaki Okuno & Sayoko Ihara & Kazushige Touhara & Nobutaka Hattori & Masatsugu Oh-Hora & Osamu Nureki & Tak, 2024. "Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Kevin Boyé & Luiz Henrique Geraldo & Jessica Furtado & Laurence Pibouin-Fragner & Mathilde Poulet & Doyeun Kim & Bryce Nelson & Yunling Xu & Laurent Jacob & Nawal Maissa & Dritan Agalliu & Lena Claess, 2022. "Endothelial Unc5B controls blood-brain barrier integrity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Andrée-Anne Berthiaume & Franca Schmid & Stefan Stamenkovic & Vanessa Coelho-Santos & Cara D. Nielson & Bruno Weber & Mark W. Majesky & Andy Y. Shih, 2022. "Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Xinhong Chen & Damien A. Wolfe & Dhanesh Sivadasan Bindu & Mengying Zhang & Naz Taskin & David Goertsen & Timothy F. Shay & Erin E. Sullivan & Sheng-Fu Huang & Sripriya Ravindra Kumar & Cynthia M. Aro, 2023. "Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    5. Jie Ding & Sung-Jin Lee & Lukas Vlahos & Kanako Yuki & Cara C. Rada & Vincent Unen & Meghah Vuppalapaty & Hui Chen & Asmiti Sura & Aaron K. McCormick & Madeline Tomaske & Samira Alwahabi & Huy Nguyen , 2023. "Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Pengfei Lu & Ping Wang & Bingruo Wu & Yidong Wang & Yang Liu & Wei Cheng & Xuhui Feng & Xinchun Yuan & Miriam M. Atteya & Haleigh Ferro & Yukiko Sugi & Grant Rydquist & Mahdi Esmaily & Jonathan T. But, 2022. "A SOX17-PDGFB signaling axis regulates aortic root development," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    7. Xue Fan Wang & Robin Vigouroux & Michal Syonov & Yuriy Baglaenko & Angeliki M. Nikolakopoulou & Dene Ringuette & Horea Rus & Peter V. DiStefano & Suzie Dufour & Alireza P. Shabanzadeh & Seunggi Lee & , 2024. "The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    8. William A. Mills & AnnaLin M. Woo & Shan Jiang & Joelle Martin & Dayana Surendran & Matthew Bergstresser & Ian F. Kimbrough & Ukpong B. Eyo & Michael V. Sofroniew & Harald Sontheimer, 2022. "Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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