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Glial and neuronal control of brain blood flow

Author

Listed:
  • David Attwell

    (Physiology and Pharmacology, University College London)

  • Alastair M. Buchan

    (Acute Stroke Programme, University of Oxford)

  • Serge Charpak

    (INSERM U603; CNRS UMR 8154; Laboratory of Neurophysiology and New Microscopies, Université Paris Descartes)

  • Martin Lauritzen

    (Institute for Neuroscience and Pharmacology, University of Copenhagen & Glostrup Hospital)

  • Brian A. MacVicar

    (University of British Columbia)

  • Eric A. Newman

    (University of Minnesota)

Abstract

Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.

Suggested Citation

  • David Attwell & Alastair M. Buchan & Serge Charpak & Martin Lauritzen & Brian A. MacVicar & Eric A. Newman, 2010. "Glial and neuronal control of brain blood flow," Nature, Nature, vol. 468(7321), pages 232-243, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7321:d:10.1038_nature09613
    DOI: 10.1038/nature09613
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    1. Domenic H. Cerri & Daniel L. Albaugh & Lindsay R. Walton & Brittany Katz & Tzu-Wen Wang & Tzu-Hao Harry Chao & Weiting Zhang & Randal J. Nonneman & Jing Jiang & Sung-Ho Lee & Amit Etkin & Catherine N., 2024. "Distinct neurochemical influences on fMRI response polarity in the striatum," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    2. Shashank Shekhar & Shaoxun Wang & Paige N Mims & Ezekiel Gonzalez-Fernandez & Chao Zhang & Xiaochen He & Catherine Y Liu & Wenshan Lv & Yangang Wang & Juebin Huang & Fan Fan, 2017. "Impaired Cerebral Autoregulation-A Common Neurovascular Pathway in Diabetes may Play a Critical Role in Diabetes-Related Alzheimer’s Disease," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 2(3), pages 1-6, June.
    3. Nicole Haack & Pavel Dublin & Christine R Rose, 2014. "Dysbalance of Astrocyte Calcium under Hyperammonemic Conditions," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-11, August.
    4. Xin Rui Lim & Mohammad M. Abd-Alhaseeb & Michael Ippolito & Masayo Koide & Amanda J. Senatore & Curtis Plante & Ashwini Hariharan & Nick Weir & Thomas A. Longden & Kathryn A. Laprade & James M. Staffo, 2024. "Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    5. Minhui Ouyang & John A. Detre & Jessica L. Hyland & Kay L. Sindabizera & Emily S. Kuschner & J. Christopher Edgar & Yun Peng & Hao Huang, 2024. "Spatiotemporal cerebral blood flow dynamics underlies emergence of the limbic-sensorimotor-association cortical gradient in human infancy," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Shashank Shekhar & Shaoxun Wang & Paige N Mims & Ezekiel Gonzalez-Fernandez & Chao Zhang & Xiaochen He & Catherine Y Liu & Wenshan Lv & Yangang Wang & Juebin Huang & Fan Fan, 2017. "Impaired Cerebral Autoregulation-A Common Neurovascular Pathway in Diabetes may Play a Critical Role in Diabetes-Related Alzheimers Disease," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 2(3), pages 40-45, June.
    7. Yu, Yangyang & Yuan, Zhixuan & Li, Jiajia & Wu, Ying, 2023. "Dynamic analysis of epileptic seizures caused by energy failure after ischemic stroke," Chaos, Solitons & Fractals, Elsevier, vol. 176(C).
    8. E. J. Mathias & M. J. Plank & T. David, 2017. "A model of neurovascular coupling and the BOLD response PART II," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 20(5), pages 519-529, April.
    9. Rita Gil & Mafalda Valente & Noam Shemesh, 2024. "Rat superior colliculus encodes the transition between static and dynamic vision modes," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    10. Marine Tournissac & Emmanuelle Chaigneau & Sonia Pfister & Ali-Kemal Aydin & Yannick Goulam Houssen & Philip O’Herron & Jessica Filosa & Mayeul Collot & Anne Joutel & Serge Charpak, 2024. "Neurovascular coupling and CO2 interrogate distinct vascular regulations," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    11. Patrick S. Hosford & Jack A. Wells & Shereen Nizari & Isabel N. Christie & Shefeeq M. Theparambil & Pablo A. Castro & Anna Hadjihambi & L. Felipe Barros & Iván Ruminot & Mark F. Lythgoe & Alexander V., 2022. "CO2 signaling mediates neurovascular coupling in the cerebral cortex," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    12. William A. Mills & AnnaLin M. Woo & Shan Jiang & Joelle Martin & Dayana Surendran & Matthew Bergstresser & Ian F. Kimbrough & Ukpong B. Eyo & Michael V. Sofroniew & Harald Sontheimer, 2022. "Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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