IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v468y2010i7321d10.1038_nature09613.html
   My bibliography  Save this article

Glial and neuronal control of brain blood flow

Author

Listed:
  • David Attwell

    (Physiology and Pharmacology, University College London)

  • Alastair M. Buchan

    (Acute Stroke Programme, University of Oxford)

  • Serge Charpak

    (INSERM U603; CNRS UMR 8154; Laboratory of Neurophysiology and New Microscopies, Université Paris Descartes)

  • Martin Lauritzen

    (Institute for Neuroscience and Pharmacology, University of Copenhagen & Glostrup Hospital)

  • Brian A. MacVicar

    (University of British Columbia)

  • Eric A. Newman

    (University of Minnesota)

Abstract

Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.

Suggested Citation

  • David Attwell & Alastair M. Buchan & Serge Charpak & Martin Lauritzen & Brian A. MacVicar & Eric A. Newman, 2010. "Glial and neuronal control of brain blood flow," Nature, Nature, vol. 468(7321), pages 232-243, November.
  • Handle: RePEc:nat:nature:v:468:y:2010:i:7321:d:10.1038_nature09613
    DOI: 10.1038/nature09613
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09613
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature09613?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Domenic H. Cerri & Daniel L. Albaugh & Lindsay R. Walton & Brittany Katz & Tzu-Wen Wang & Tzu-Hao Harry Chao & Weiting Zhang & Randal J. Nonneman & Jing Jiang & Sung-Ho Lee & Amit Etkin & Catherine N., 2024. "Distinct neurochemical influences on fMRI response polarity in the striatum," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    2. Shashank Shekhar & Shaoxun Wang & Paige N Mims & Ezekiel Gonzalez-Fernandez & Chao Zhang & Xiaochen He & Catherine Y Liu & Wenshan Lv & Yangang Wang & Juebin Huang & Fan Fan, 2017. "Impaired Cerebral Autoregulation-A Common Neurovascular Pathway in Diabetes may Play a Critical Role in Diabetes-Related Alzheimer’s Disease," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 2(3), pages 1-6, June.
    3. Nicole Haack & Pavel Dublin & Christine R Rose, 2014. "Dysbalance of Astrocyte Calcium under Hyperammonemic Conditions," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-11, August.
    4. Shashank Shekhar & Shaoxun Wang & Paige N Mims & Ezekiel Gonzalez-Fernandez & Chao Zhang & Xiaochen He & Catherine Y Liu & Wenshan Lv & Yangang Wang & Juebin Huang & Fan Fan, 2017. "Impaired Cerebral Autoregulation-A Common Neurovascular Pathway in Diabetes may Play a Critical Role in Diabetes-Related Alzheimers Disease," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 2(3), pages 40-45, June.
    5. Yu, Yangyang & Yuan, Zhixuan & Li, Jiajia & Wu, Ying, 2023. "Dynamic analysis of epileptic seizures caused by energy failure after ischemic stroke," Chaos, Solitons & Fractals, Elsevier, vol. 176(C).
    6. E. J. Mathias & M. J. Plank & T. David, 2017. "A model of neurovascular coupling and the BOLD response PART II," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 20(5), pages 519-529, April.
    7. Rita Gil & Mafalda Valente & Noam Shemesh, 2024. "Rat superior colliculus encodes the transition between static and dynamic vision modes," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    8. Marine Tournissac & Emmanuelle Chaigneau & Sonia Pfister & Ali-Kemal Aydin & Yannick Goulam Houssen & Philip O’Herron & Jessica Filosa & Mayeul Collot & Anne Joutel & Serge Charpak, 2024. "Neurovascular coupling and CO2 interrogate distinct vascular regulations," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    9. Patrick S. Hosford & Jack A. Wells & Shereen Nizari & Isabel N. Christie & Shefeeq M. Theparambil & Pablo A. Castro & Anna Hadjihambi & L. Felipe Barros & Iván Ruminot & Mark F. Lythgoe & Alexander V., 2022. "CO2 signaling mediates neurovascular coupling in the cerebral cortex," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    10. William A. Mills & AnnaLin M. Woo & Shan Jiang & Joelle Martin & Dayana Surendran & Matthew Bergstresser & Ian F. Kimbrough & Ukpong B. Eyo & Michael V. Sofroniew & Harald Sontheimer, 2022. "Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:468:y:2010:i:7321:d:10.1038_nature09613. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.