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Ptychographic X-ray computed tomography at the nanoscale

Author

Listed:
  • Martin Dierolf

    (Technische Universität München)

  • Andreas Menzel

    (Swiss Light Source, Paul Scherrer Institut)

  • Pierre Thibault

    (Technische Universität München)

  • Philipp Schneider

    (Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland)

  • Cameron M. Kewish

    (Swiss Light Source, Paul Scherrer Institut
    Present address: Synchrotron SOLEIL, Saint-Aubin BP-48, 91192 Gif-sur-Yvette, France.)

  • Roger Wepf

    (Electron Microscopy ETH Zurich (EMEZ))

  • Oliver Bunk

    (Swiss Light Source, Paul Scherrer Institut)

  • Franz Pfeiffer

    (Technische Universität München)

Abstract

Nanoscale computed tomography Established X-ray tomography techniques can reveal the three-dimensional internal structure of entire organisms and of single cells, as well as quantitative information, usually calculated from X-ray attenuation data. A newly emerging X-ray computed tomography technique that uses 'ptychographic' X-ray imaging — which can extract detailed phase contrast information from even weakly absorbing objects — is now taking quantitative X-ray imaging into the nanoworld. Sensitive to density variations of less than 1%, the potential of the new method is demonstrated by producing three-dimensional images of a bone specimen in which structures on the 100-nanometre scale, such as the osteocyte lacunae and the interconnective canalicular network, are clearly resolved. High-resolution quantitative tomography of this type may find applications in biomedicine and in microanalysis of fossils as well as in materials science.

Suggested Citation

  • Martin Dierolf & Andreas Menzel & Pierre Thibault & Philipp Schneider & Cameron M. Kewish & Roger Wepf & Oliver Bunk & Franz Pfeiffer, 2010. "Ptychographic X-ray computed tomography at the nanoscale," Nature, Nature, vol. 467(7314), pages 436-439, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7314:d:10.1038_nature09419
    DOI: 10.1038/nature09419
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    Citations

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    Cited by:

    1. Philipp M. Pelz & Sinéad M. Griffin & Scott Stonemeyer & Derek Popple & Hannah DeVyldere & Peter Ercius & Alex Zettl & Mary C. Scott & Colin Ophus, 2023. "Solving complex nanostructures with ptychographic atomic electron tomography," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Zhiyuan Ding & Si Gao & Weina Fang & Chen Huang & Liqi Zhou & Xudong Pei & Xiaoguo Liu & Xiaoqing Pan & Chunhai Fan & Angus I. Kirkland & Peng Wang, 2022. "Three-dimensional electron ptychography of organic–inorganic hybrid nanostructures," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Shiva Shirani & Ana Cuesta & Alejandro Morales-Cantero & Isabel Santacruz & Ana Diaz & Pavel Trtik & Mirko Holler & Alexander Rack & Bratislav Lukic & Emmanuel Brun & Inés R. Salcedo & Miguel A. G. Ar, 2023. "4D nanoimaging of early age cement hydration," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Simon Müller & Christina Sauter & Ramesh Shunmugasundaram & Nils Wenzler & Vincent Andrade & Francesco Carlo & Ender Konukoglu & Vanessa Wood, 2021. "Deep learning-based segmentation of lithium-ion battery microstructures enhanced by artificially generated electrodes," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    5. Xudong Pei & Liqi Zhou & Chen Huang & Mark Boyce & Judy S. Kim & Emanuela Liberti & Yiming Hu & Takeo Sasaki & Peter D. Nellist & Peijun Zhang & David I. Stuart & Angus I. Kirkland & Peng Wang, 2023. "Cryogenic electron ptychographic single particle analysis with wide bandwidth information transfer," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    6. Peng Li & Nicholas W. Phillips & Steven Leake & Marc Allain & Felix Hofmann & Virginie Chamard, 2021. "Revealing nano-scale lattice distortions in implanted material with 3D Bragg ptychography," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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