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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Author

Listed:
  • Shinsuke Ito

    (Howard Hughes Medical Institute,
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA)

  • Ana C. D’Alessio

    (Howard Hughes Medical Institute,
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA)

  • Olena V. Taranova

    (Howard Hughes Medical Institute,
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA)

  • Kwonho Hong

    (Howard Hughes Medical Institute,
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA)

  • Lawrence C. Sowers

    (Loma Linda University School of Medicine)

  • Yi Zhang

    (Howard Hughes Medical Institute,
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA)

Abstract

Tet proteins and DNA demethylation The enzymes responsible for methylating DNA, a ubiquitous epigenetic modification, have been extensively studied. Less is known about demethylation. Here, Tet1, an enzyme that catalyses the conversion of 5-methylcytosine of DNA to 5-hydroxyl-methylcytosine, is shown to have a role in mouse embryonic stem-cell maintenance by maintaining the expression of Nanog and preserving the Nanog promoter in a hypomethylated state. This suggests that Tet1 has a role in regulating DNA methylation, as well as in embryonic stem-cell self-renewal and inner cell mass specification.

Suggested Citation

  • Shinsuke Ito & Ana C. D’Alessio & Olena V. Taranova & Kwonho Hong & Lawrence C. Sowers & Yi Zhang, 2010. "Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification," Nature, Nature, vol. 466(7310), pages 1129-1133, August.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7310:d:10.1038_nature09303
    DOI: 10.1038/nature09303
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    Cited by:

    1. Youping Tian & Xiaoyu Zhou & Maohua Miao & De-kun Li & Ziliang Wang & Runsheng Li & Hong Liang & Wei Yuan, 2018. "Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen," IJERPH, MDPI, vol. 15(8), pages 1-10, August.
    2. Jianfang Li & Xinwei Wu & Jie Ke & Minjung Lee & Qingping Lan & Jia Li & Jianxiu Yu & Yun Huang & De-Qiang Sun & Ruiyu Xie, 2022. "TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Min Kyung Lee & Nasim Azizgolshani & Ze Zhang & Laurent Perreard & Fred W. Kolling & Lananh N. Nguyen & George J. Zanazzi & Lucas A. Salas & Brock C. Christensen, 2024. "Associations in cell type-specific hydroxymethylation and transcriptional alterations of pediatric central nervous system tumors," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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