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Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen

Author

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  • Youping Tian

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China
    School of Public Health, Fudan University, Shanghai 200032, China
    These two authors contributed equally.)

  • Xiaoyu Zhou

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China
    These two authors contributed equally.)

  • Maohua Miao

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China)

  • De-kun Li

    (Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente Northern California, Oakland, CA 94612, USA)

  • Ziliang Wang

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China)

  • Runsheng Li

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China)

  • Hong Liang

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China)

  • Wei Yuan

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China)

Abstract

Bisphenol A (BPA), an exogenous endocrine-disrupting chemical, has been shown to alter DNA methylation. However, little information is available about the effect of BPA exposure on DNA hydroxymethylation in humans. The objective of the present study was to examine whether BPA exposure was associated with DNA hydroxymethylation in human semen samples. We measured urine BPA levels and LINE-1 hydroxymethylation in 158 male factory workers selected from an occupational cohort study conducted in China between 2004 and 2008. Among them, there were 72 male workers with occupational BPA exposure (BPA-exposed group) and 86 male workers without occupational BPA exposure (unexposed group). Multivariate linear regression models were used to examine the association of exposure to BPA with LINE-1 hydroxymethylation. LINE-1 was more highly hydroxymethylated in the BPA-exposed group than in the unexposed group (median 12.97% vs. 9.68%, respectively; p < 0.05), after adjusting for the potential confounders. The medians of 5-hydroxymethylcytosine (5hmC) generally increased with increasing urine BPA levels: 8.79%, 12.16%, 11.53%, and 13.45%, for undetected BPA and corresponding tertiles for the detected BPA, respectively. After analysis using data at individual level, our findings indicated that BPA exposure was associated with alterations of sperm LINE-1 hydroxymethylation, which might have implications for understanding the mechanisms underlying BPA-induced adverse effects on male reproductive function.

Suggested Citation

  • Youping Tian & Xiaoyu Zhou & Maohua Miao & De-kun Li & Ziliang Wang & Runsheng Li & Hong Liang & Wei Yuan, 2018. "Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen," IJERPH, MDPI, vol. 15(8), pages 1-10, August.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:8:p:1770-:d:164228
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    References listed on IDEAS

    as
    1. Kristine Williams & Jesper Christensen & Marianne Terndrup Pedersen & Jens V. Johansen & Paul A. C. Cloos & Juri Rappsilber & Kristian Helin, 2011. "TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity," Nature, Nature, vol. 473(7347), pages 343-348, May.
    2. Shinsuke Ito & Ana C. D’Alessio & Olena V. Taranova & Kwonho Hong & Lawrence C. Sowers & Yi Zhang, 2010. "Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification," Nature, Nature, vol. 466(7310), pages 1129-1133, August.
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