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KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints

Author

Listed:
  • David N. Ciccone

    (Epigenetics Program,
    Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA)

  • Hui Su

    (Epigenetics Program,
    Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA)

  • Sarah Hevi

    (Epigenetics Program,
    Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA)

  • Frédérique Gay

    (Epigenetics Program,
    Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA)

  • Hong Lei

    (Epigenetics Program,
    Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA)

  • Jeffrey Bajko

    (Epigenetics Program,
    Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA)

  • Guoliang Xu

    (The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China)

  • En Li

    (Epigenetics Program,)

  • Taiping Chen

    (Epigenetics Program,
    Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA)

Abstract

Genomic imprinting: histone demethylation precedes DNA methylation Differential DNA methylation of paternal and maternal alleles regulates the parental origin-specific expression of imprinted genes in mammals, but it is unclear how particular imprinted loci are selected for de novo DNA methylation during gametogenesis. Here, AOF1/KDM1B is shown to be a histone H3 lysine 4 (H3K4) demethylase that is expressed in growing oocytes and required for the establishment of DNA methylation at certain imprinted genes. This suggests that demethylation of H3K4 plays an important role in the formation of DNA methylation imprints at these loci during oogenesis.

Suggested Citation

  • David N. Ciccone & Hui Su & Sarah Hevi & Frédérique Gay & Hong Lei & Jeffrey Bajko & Guoliang Xu & En Li & Taiping Chen, 2009. "KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints," Nature, Nature, vol. 461(7262), pages 415-418, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7262:d:10.1038_nature08315
    DOI: 10.1038/nature08315
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    Cited by:

    1. Seiichi Yano & Takashi Ishiuchi & Shusaku Abe & Satoshi H. Namekawa & Gang Huang & Yoshihiro Ogawa & Hiroyuki Sasaki, 2022. "Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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