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A mechanism linking extra centrosomes to chromosomal instability

Author

Listed:
  • Neil J. Ganem

    (Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Susana A. Godinho

    (Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • David Pellman

    (Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Chromosome instability: extra centrosomes do battle in tug of war The mechanism underlying chromosomal instability (CIN), an increased rate of gain or loss of whole chromosomes that is common in cancer cells, has been the subject of much debate. Long-term live-cell imaging now reveals that extra-centrosomal cancer cells pass through a transitory multipolar spindle stage, when abnormal kinetochore-microtubule attachments accumulate. Many attachment errors persist even after the extra centrosomes cluster to form proper bipolar spindles, increasing the likelihood of chromosome missegregation. The cover shows a transient multipolar spindle intermediate in a human cell with extra centrosomes. Microtubules are shown red, centrosomes green and chromosomes white.

Suggested Citation

  • Neil J. Ganem & Susana A. Godinho & David Pellman, 2009. "A mechanism linking extra centrosomes to chromosomal instability," Nature, Nature, vol. 460(7252), pages 278-282, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7252:d:10.1038_nature08136
    DOI: 10.1038/nature08136
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    Cited by:

    1. Marina A. Schapfl & Gina M. LoMastro & Vincent Z. Braun & Maretoshi Hirai & Michelle S. Levine & Eva Kiermaier & Verena Labi & Andrew J. Holland & Andreas Villunger, 2024. "Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Chunyang Bao & Richard W. Tourdot & Gregory J. Brunette & Chip Stewart & Lili Sun & Hideo Baba & Masayuki Watanabe & Agoston T. Agoston & Kunal Jajoo & Jon M. Davison & Katie S. Nason & Gad Getz & Ken, 2023. "Genomic signatures of past and present chromosomal instability in Barrett’s esophagus and early esophageal adenocarcinoma," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    3. Carolin M. Sauer & James A. Hall & Dominique-Laurent Couturier & Thomas Bradley & Anna M. Piskorz & Jacob Griffiths & Ashley Sawle & Matthew D. Eldridge & Philip Smith & Karen Hosking & Marika A. V. R, 2023. "Molecular landscape and functional characterization of centrosome amplification in ovarian cancer," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Guidantonio Malagoli Tagliazucchi & Anna J. Wiecek & Eloise Withnell & Maria Secrier, 2023. "Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    5. Bernardo P de Almeida & André F Vieira & Joana Paredes & Mónica Bettencourt-Dias & Nuno L Barbosa-Morais, 2019. "Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome," PLOS Computational Biology, Public Library of Science, vol. 15(3), pages 1-31, March.
    6. Eleanor L. Woodward & Minjun Yang & Larissa H. Moura-Castro & Hilda Bos & Rebeqa Gunnarsson & Linda Olsson-Arvidsson & Diana C. J. Spierings & Anders Castor & Nicolas Duployez & Marketa Zaliova & Jan , 2023. "Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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