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mTOR regulates memory CD8 T-cell differentiation

Author

Listed:
  • Koichi Araki

    (Emory Vaccine Center and Department of Microbiology and Immunology,)

  • Alexandra P. Turner

    (Emory University School of Medicine, Atlanta, Georgia 30322, USA)

  • Virginia Oliva Shaffer

    (Emory University School of Medicine, Atlanta, Georgia 30322, USA)

  • Shivaprakash Gangappa

    (Emory University School of Medicine, Atlanta, Georgia 30322, USA)

  • Susanne A. Keller

    (Cytos Biotechnology AG, Wagistrasse 25, 8952 Zürich-Schlieren, Switzerland)

  • Martin F. Bachmann

    (Cytos Biotechnology AG, Wagistrasse 25, 8952 Zürich-Schlieren, Switzerland)

  • Christian P. Larsen

    (Emory University School of Medicine, Atlanta, Georgia 30322, USA)

  • Rafi Ahmed

    (Emory Vaccine Center and Department of Microbiology and Immunology,)

Abstract

T-cell memory regulation by mTOR mTOR, part of the PI3K–AKT–mTOR cell-signalling cascade and a target for the antitumour drug rapamycin, is identified here as a regulator of CD8 T-cell differentiation. Despite its primarily immunosuppressive activity, rapamycin can enhance immune responses to experimental vaccines in mice and monkeys. This counterintuitive finding points to the ability to increase the functional qualities of memory T cells as a potential way of enhancing the efficacy of vaccines against pathogens and cancers.

Suggested Citation

  • Koichi Araki & Alexandra P. Turner & Virginia Oliva Shaffer & Shivaprakash Gangappa & Susanne A. Keller & Martin F. Bachmann & Christian P. Larsen & Rafi Ahmed, 2009. "mTOR regulates memory CD8 T-cell differentiation," Nature, Nature, vol. 460(7251), pages 108-112, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7251:d:10.1038_nature08155
    DOI: 10.1038/nature08155
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    Cited by:

    1. Alexandria C. Wells & Kaito A. Hioki & Constance C. Angelou & Adam C. Lynch & Xueting Liang & Daniel J. Ryan & Iris Thesmar & Saule Zhanybekova & Saulius Zuklys & Jacob Ullom & Agnes Cheong & Jesse Ma, 2023. "Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Viviana Volta & Sandra Pérez-Baos & Columba Parra & Olga Katsara & Amanda Ernlund & Sophie Dornbaum & Robert J. Schneider, 2021. "A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    3. Joshua M. Gammon & Sean T. Carey & Vikas Saxena & Haleigh B. Eppler & Shannon J. Tsai & Christina Paluskievicz & Yanbao Xiong & Lushen Li & Marian Ackun-Farmmer & Lisa H. Tostanoski & Emily A. Gosseli, 2023. "Engineering the lymph node environment promotes antigen-specific efficacy in type 1 diabetes and islet transplantation," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Diane Maurice & Patrick Costello & Jessica Diring & Francesco Gualdrini & Bruno Frederico & Richard Treisman, 2024. "IL-2 delivery to CD8+ T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    5. Victor Joo & Karim Abdelhamid & Alessandra Noto & Sofiya Latifyan & Federica Martina & Douglas Daoudlarian & Rita De Micheli & Menno Pruijm & Solange Peters & Roger Hullin & Olivier Gaide & Giuseppe P, 2024. "Primary prophylaxis with mTOR inhibitor enhances T cell effector function and prevents heart transplant rejection during talimogene laherparepvec therapy of squamous cell carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    6. Luca Simula & Mattia Fumagalli & Lene Vimeux & Irena Rajnpreht & Philippe Icard & Gary Birsen & Dongjie An & Frédéric Pendino & Adrien Rouault & Nadège Bercovici & Diane Damotte & Audrey Lupo-Mansuet , 2024. "Mitochondrial metabolism sustains CD8+ T cell migration for an efficient infiltration into solid tumors," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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