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Unlocking the molecular secrets of sodium-coupled transporters

Author

Listed:
  • Harini Krishnamurthy

    (Vollum Institute, Oregon Health and Science University)

  • Chayne L. Piscitelli

    (Vollum Institute, Oregon Health and Science University
    Department of Biochemistry and Molecular Biology Oregon Health and Science University)

  • Eric Gouaux

    (Vollum Institute, Oregon Health and Science University
    Howard Hughes Medical Institute, Oregon Health and Science University)

Abstract

Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numerous diseases. Within the past year, crystal structures of several sodium-coupled transporters from different families have been reported, showing a remarkable structural conservation between functionally unrelated transporters. These atomic-resolution structures are revealing the mechanism of the sodium-coupled transport of solutes across cellular membranes.

Suggested Citation

  • Harini Krishnamurthy & Chayne L. Piscitelli & Eric Gouaux, 2009. "Unlocking the molecular secrets of sodium-coupled transporters," Nature, Nature, vol. 459(7245), pages 347-355, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7245:d:10.1038_nature08143
    DOI: 10.1038/nature08143
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    Cited by:

    1. Yongchan Lee & Pattama Wiriyasermkul & Pornparn Kongpracha & Satomi Moriyama & Deryck J. Mills & Werner Kühlbrandt & Shushi Nagamori, 2022. "Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Victoria C. Young & Hanayo Nakanishi & Dylan J. Meyer & Tomohiro Nishizawa & Atsunori Oshima & Pablo Artigas & Kazuhiro Abe, 2022. "Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Hyun Deok Song & Fangqiang Zhu, 2015. "Conformational Changes in Two Inter-Helical Loops of Mhp1 Membrane Transporter," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-19, July.
    4. Patrick Roth & Jean-Marc Jeckelmann & Inken Fender & Zöhre Ucurum & Thomas Lemmin & Dimitrios Fotiadis, 2024. "Structure and mechanism of a phosphotransferase system glucose transporter," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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