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Crystal structure of the sodium–potassium pump at 2.4 Å resolution

Author

Listed:
  • Takehiro Shinoda

    (Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Haruo Ogawa

    (Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Flemming Cornelius

    (University of Aarhus)

  • Chikashi Toyoshima

    (Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan)

Abstract

Na+, K+-ATPase structure The sodium-potassium ATPase is an ATP-powered ion pump that creates concentration gradients for sodium and potassium ions across the plasma membrane of animal cells. Sodium ions are exported from the cell while potassium ions are imported producing gradients that are used for many essential processes, such as the action potentials of nerve cells. The crystal structure of this protein from shark rectal gland — highly homologous to the human version — has now been determined at 2.4 Å resolution. The structure helps elucidate many details of the protein's mechanism of action and will contribute, among other things, to the understanding and treatment of heart disease, since cardiac glycosides are inhibitors of the sodium-potassium pump.

Suggested Citation

  • Takehiro Shinoda & Haruo Ogawa & Flemming Cornelius & Chikashi Toyoshima, 2009. "Crystal structure of the sodium–potassium pump at 2.4 Å resolution," Nature, Nature, vol. 459(7245), pages 446-450, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7245:d:10.1038_nature07939
    DOI: 10.1038/nature07939
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    Cited by:

    1. Phong T. Nguyen & Christine Deisl & Michael Fine & Trevor S. Tippetts & Emiko Uchikawa & Xiao-chen Bai & Beth Levine, 2022. "Structural basis for gating mechanism of the human sodium-potassium pump," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Yingying Guo & Yuanyuan Zhang & Renhong Yan & Bangdong Huang & Fangfei Ye & Liushu Wu & Ximin Chi & Yi shi & Qiang Zhou, 2022. "Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Victoria C. Young & Hanayo Nakanishi & Dylan J. Meyer & Tomohiro Nishizawa & Atsunori Oshima & Pablo Artigas & Kazuhiro Abe, 2022. "Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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