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The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

Author

Listed:
  • Camilla Raiborg

    (Centre for Cancer Biomedicine, Norwegian Radium Hospital, University of Oslo
    Institute for Cancer Research, Rikshospitalet University Hospital)

  • Harald Stenmark

    (Centre for Cancer Biomedicine, Norwegian Radium Hospital, University of Oslo
    Institute for Cancer Research, Rikshospitalet University Hospital)

Abstract

Selective trafficking of membrane proteins to lysosomes for destruction is required for proper cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins should be transported to the lysosome lumen by the multivesicular endosome pathway. The endosomal sorting complex required for transport (ESCRT) machinery sorts cargo labelled with ubiquitin into invaginations of endosome membranes. Then, through a highly conserved mechanism also used in cytokinesis and viral budding, it mediates the breaking off of the cargo-containing intraluminal vesicles from the perimeter membrane. The involvement of the ESCRT machinery in suppressing diseases such as cancer, neurodegeneration and infections underscores its importance to the cell.

Suggested Citation

  • Camilla Raiborg & Harald Stenmark, 2009. "The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins," Nature, Nature, vol. 458(7237), pages 445-452, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7237:d:10.1038_nature07961
    DOI: 10.1038/nature07961
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    Cited by:

    1. Tomoyuki Hatano & Saravanan Palani & Dimitra Papatziamou & Ralf Salzer & Diorge P. Souza & Daniel Tamarit & Mehul Makwana & Antonia Potter & Alexandra Haig & Wenjue Xu & David Townsend & David Rochest, 2022. "Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Jin-Xin Zheng & Tong-Yang Du & Guang-Can Shao & Zhu-Hui Ma & Zhao-Di Jiang & Wen Hu & Fang Suo & Wanzhong He & Meng-Qiu Dong & Li-Lin Du, 2023. "Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of fission yeast wtf meiotic drivers," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Yonglun Zeng & Baiying Li & Shuxian Huang & Hongbo Li & Wenhan Cao & Yixuan Chen & Guoyong Liu & Zhenping Li & Chao Yang & Lei Feng & Jiayang Gao & Sze Wan Lo & Jierui Zhao & Jinbo Shen & Yan Guo & Ca, 2023. "The plant unique ESCRT component FREE1 regulates autophagosome closure," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Sarah Renaud & Anthony Lefebvre & Olivier Moralès & Nadira Delhem, 2019. "Mini Review - Exosomes from Discovery to Isolation," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 15(2), pages 11286-11293, February.
    5. Meihua Jin & Hiroki Shiwaku & Hikari Tanaka & Takayuki Obita & Sakurako Ohuchi & Yuki Yoshioka & Xiaocen Jin & Kanoh Kondo & Kyota Fujita & Hidenori Homma & Kazuyuki Nakajima & Mineyuki Mizuguchi & Hi, 2021. "Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation," Nature Communications, Nature, vol. 12(1), pages 1-22, December.
    6. Torben Mentrup & Anna Yamina Stumpff-Niggemann & Nadja Leinung & Christine Schlosser & Katja Schubert & Rebekka Wehner & Antje Tunger & Valentin Schatz & Patrick Neubert & Ann-Christine Gradtke & Jani, 2022. "Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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