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Pulsed contractions of an actin–myosin network drive apical constriction

Author

Listed:
  • Adam C. Martin

    (Howard Hughes Medical Institute,
    Department of Molecular Biology,)

  • Matthias Kaschube

    (Lewis-Sigler Institute for Integrative Genomics, and,
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, New Jersey 08544, USA)

  • Eric F. Wieschaus

    (Howard Hughes Medical Institute,
    Department of Molecular Biology,)

Abstract

The shape of cells to come During development, changes in individual cell shape drive the overall organization of organs and tissues. Now a study of the dynamics of cell behaviour during fruit fly development reveals a previously unknown ratchet-like mechanism that drives cell shape change. Gastrulation in the Drosophila embryo involves the apical constriction of ventral cells, which induces a ventral furrow and invagination of the mesoderm. This new work shows that the apical constriction of ventral cells is pulsed: repeated constrictions are interrupted by pauses in which the constricted state of the cells in maintained. These pulses are powered by actin–myosin contractions and are dependent on the expression of a transcription factor Snail, whereas the constricted state is stabilized by another transcription factor, Twist.

Suggested Citation

  • Adam C. Martin & Matthias Kaschube & Eric F. Wieschaus, 2009. "Pulsed contractions of an actin–myosin network drive apical constriction," Nature, Nature, vol. 457(7228), pages 495-499, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7228:d:10.1038_nature07522
    DOI: 10.1038/nature07522
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    Cited by:

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