IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v457y2009i7228d10.1038_nature07522.html
   My bibliography  Save this article

Pulsed contractions of an actin–myosin network drive apical constriction

Author

Listed:
  • Adam C. Martin

    (Howard Hughes Medical Institute,
    Department of Molecular Biology,)

  • Matthias Kaschube

    (Lewis-Sigler Institute for Integrative Genomics, and,
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, New Jersey 08544, USA)

  • Eric F. Wieschaus

    (Howard Hughes Medical Institute,
    Department of Molecular Biology,)

Abstract

The shape of cells to come During development, changes in individual cell shape drive the overall organization of organs and tissues. Now a study of the dynamics of cell behaviour during fruit fly development reveals a previously unknown ratchet-like mechanism that drives cell shape change. Gastrulation in the Drosophila embryo involves the apical constriction of ventral cells, which induces a ventral furrow and invagination of the mesoderm. This new work shows that the apical constriction of ventral cells is pulsed: repeated constrictions are interrupted by pauses in which the constricted state of the cells in maintained. These pulses are powered by actin–myosin contractions and are dependent on the expression of a transcription factor Snail, whereas the constricted state is stabilized by another transcription factor, Twist.

Suggested Citation

  • Adam C. Martin & Matthias Kaschube & Eric F. Wieschaus, 2009. "Pulsed contractions of an actin–myosin network drive apical constriction," Nature, Nature, vol. 457(7228), pages 495-499, January.
  • Handle: RePEc:nat:nature:v:457:y:2009:i:7228:d:10.1038_nature07522
    DOI: 10.1038/nature07522
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07522
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature07522?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hannah J. Gustafson & Nikolas Claussen & Stefano Renzis & Sebastian J. Streichan, 2022. "Patterned mechanical feedback establishes a global myosin gradient," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Nabila Founounou & Reza Farhadifar & Giovanna M. Collu & Ursula Weber & Michael J. Shelley & Marek Mlodzik, 2021. "Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    3. Sijia Zhou & Peng Li & Jiaying Liu & Juan Liao & Hao Li & Lin Chen & Zhihua Li & Qiongyu Guo & Karine Belguise & Bin Yi & Xiaobo Wang, 2022. "Two Rac1 pools integrate the direction and coordination of collective cell migration," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    4. Bibi Najma & Minu Varghese & Lev Tsidilkovski & Linnea Lemma & Aparna Baskaran & Guillaume Duclos, 2022. "Competing instabilities reveal how to rationally design and control active crosslinked gels," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    5. Guilherme Ventura & Aboutaleb Amiri & Raghavan Thiagarajan & Mari Tolonen & Amin Doostmohammadi & Jakub Sedzinski, 2022. "Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    6. Shun Li & Zong-Yuan Liu & Hao Li & Sijia Zhou & Jiaying Liu & Ningwei Sun & Kai-Fu Yang & Vanessa Dougados & Thomas Mangeat & Karine Belguise & Xi-Qiao Feng & Yiyao Liu & Xiaobo Wang, 2024. "Basal actomyosin pulses expand epithelium coordinating cell flattening and tissue elongation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    7. Aurélien Villedieu & Lale Alpar & Isabelle Gaugué & Amina Joudat & François Graner & Floris Bosveld & Yohanns Bellaïche, 2023. "Homeotic compartment curvature and tension control spatiotemporal folding dynamics," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    8. Özge Özgüç & Ludmilla de Plater & Varun Kapoor & Anna Francesca Tortorelli & Andrew G Clark & Jean-Léon Maître, 2022. "Cortical softening elicits zygotic contractility during mouse preimplantation development," PLOS Biology, Public Library of Science, vol. 20(3), pages 1-23, March.
    9. Alexis Villars & Alexis Matamoro-Vidal & Florence Levillayer & Romain Levayer, 2022. "Microtubule disassembly by caspases is an important rate-limiting step of cell extrusion," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:457:y:2009:i:7228:d:10.1038_nature07522. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.