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Experience with moving visual stimuli drives the early development of cortical direction selectivity

Author

Listed:
  • Ye Li

    (Duke University School of Medicine)

  • Stephen D. Van Hooser

    (Duke University School of Medicine)

  • Mark Mazurek

    (Duke University School of Medicine)

  • Leonard E. White

    (Duke University School of Medicine
    Duke University School of Medicine)

  • David Fitzpatrick

    (Duke University School of Medicine
    Duke Institute for Brain Sciences, Duke University, Durham, North Carolina 27710, USA.)

Abstract

Cortical development: following the light Neural circuits in the visual cortex are immature at birth, and require exposure to visual stimuli to form the connections and selectivity of the mature visual system. To date, just how stimulus driven neural activity guides the emergence of properties such as direction selectivity has been unclear. Li et al. now track this process with a combination of intrinsic and two-photon calcium imaging in visually naive ferrets. After exposing the animals to stimuli moving along one single axis of motion, they find that selectivity for those directions emerges rapidly as well as the local organization of direction preference between neighbouring cells.

Suggested Citation

  • Ye Li & Stephen D. Van Hooser & Mark Mazurek & Leonard E. White & David Fitzpatrick, 2008. "Experience with moving visual stimuli drives the early development of cortical direction selectivity," Nature, Nature, vol. 456(7224), pages 952-956, December.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7224:d:10.1038_nature07417
    DOI: 10.1038/nature07417
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    Cited by:

    1. Lars Reichl & Dominik Heide & Siegrid Löwel & Justin C Crowley & Matthias Kaschube & Fred Wolf, 2012. "Coordinated Optimization of Visual Cortical Maps (II) Numerical Studies," PLOS Computational Biology, Public Library of Science, vol. 8(11), pages 1-26, November.
    2. Jeremy T. Chang & David Fitzpatrick, 2022. "Development of visual response selectivity in cortical GABAergic interneurons," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Stuart Yarrow & Khaleel A Razak & Aaron R Seitz & Peggy Seriès, 2014. "Detecting and Quantifying Topography in Neural Maps," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-14, February.

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