IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-31284-6.html
   My bibliography  Save this article

Development of visual response selectivity in cortical GABAergic interneurons

Author

Listed:
  • Jeremy T. Chang

    (Max Planck Florida Institute for Neuroscience)

  • David Fitzpatrick

    (Max Planck Florida Institute for Neuroscience)

Abstract

The visual cortex of carnivores and primates displays a high degree of modular network organization characterized by local clustering and structured long-range correlations of activity and functional properties. Excitatory networks display modular organization before the onset of sensory experience, but the developmental timeline for modular networks of GABAergic interneurons remains under-explored. Using in vivo calcium imaging of the ferret visual cortex, we find evidence that before visual experience, interneurons display weak orientation tuning and widespread, correlated activity in response to visual stimuli. Robust modular organization and orientation tuning are evident with as little as one week of visual experience. Furthermore, we find that the maturation of orientation tuning requires visual experience, while the reduction in widespread, correlated network activity does not. Thus, the maturation of inhibitory cortical networks occurs in a delayed, parallel process relative to excitatory neurons.

Suggested Citation

  • Jeremy T. Chang & David Fitzpatrick, 2022. "Development of visual response selectivity in cortical GABAergic interneurons," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31284-6
    DOI: 10.1038/s41467-022-31284-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-31284-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-31284-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ye Li & Stephen D. Van Hooser & Mark Mazurek & Leonard E. White & David Fitzpatrick, 2008. "Experience with moving visual stimuli drives the early development of cortical direction selectivity," Nature, Nature, vol. 456(7224), pages 952-956, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Stuart Yarrow & Khaleel A Razak & Aaron R Seitz & Peggy Seriès, 2014. "Detecting and Quantifying Topography in Neural Maps," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-14, February.
    2. Lars Reichl & Dominik Heide & Siegrid Löwel & Justin C Crowley & Matthias Kaschube & Fred Wolf, 2012. "Coordinated Optimization of Visual Cortical Maps (II) Numerical Studies," PLOS Computational Biology, Public Library of Science, vol. 8(11), pages 1-26, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31284-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.