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Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960

Author

Listed:
  • Michael Worobey

    (Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA)

  • Marlea Gemmel

    (Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA)

  • Dirk E. Teuwen

    (Sanofi Pasteur
    UCB SA Pharma, Braine l’Alleud, BE-1420, Belgium)

  • Tamara Haselkorn

    (Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA)

  • Kevin Kunstman

    (The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA)

  • Michael Bunce

    (Ancient DNA Laboratory, School of Biological Sciences and Biotechnology, Murdoch University, Perth, Western Australia 6150, Australia)

  • Jean-Jacques Muyembe

    (University of Kinshasa
    National Institute for Biomedical Research, National Laboratory of Public Health)

  • Jean-Marie M. Kabongo

    (University of Kinshasa)

  • Raphaël M. Kalengayi

    (University of Kinshasa)

  • Eric Van Marck

    (University Hospital, University of Antwerp)

  • M. Thomas P. Gilbert

    (Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Present address: Centre for Ancient Genetics, Biological Institute, University of Copenhagen, Copenhagen DK-2100, Denmark.)

  • Steven M. Wolinsky

    (The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA)

Abstract

HIV/AIDS then and now A histological specimen from the University of Kinshasa archives has been used to obtain HIV gene sequences dating back to the pre-AIDS era. From a lymph node biopsy taken in 1960 from an adult female in Léopoldville in the Belgian Congo (now Kinshasa, Democratic Republic of the Congo), sample 'DRC60' makes possible the first evolutionary analysis of pre-AIDS 'fossil' HIV-1 sequences, via comparison with the one other viral sequence from the period, from a plasma sample taken in 1959, also in Kinshasa. The analysis supports the idea that diversification of HIV-1 in west-central Africa occurred long before the recognized AIDS pandemic. Almost fifty years on, a major concern in HIV epidemiology is China. Here, HIV-1 infection was largely confined to high-risk groups but it is now breaking out into the general population. Lin Lu et al. report on efforts to contain the epidemic in Yunnan Province, where there has been a dramatic increase in sexual transmission of HIV.

Suggested Citation

  • Michael Worobey & Marlea Gemmel & Dirk E. Teuwen & Tamara Haselkorn & Kevin Kunstman & Michael Bunce & Jean-Jacques Muyembe & Jean-Marie M. Kabongo & Raphaël M. Kalengayi & Eric Van Marck & M. Thomas , 2008. "Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960," Nature, Nature, vol. 455(7213), pages 661-664, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7213:d:10.1038_nature07390
    DOI: 10.1038/nature07390
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    Cited by:

    1. Aridaman Pandit & Somdatta Sinha, 2011. "Differential Trends in the Codon Usage Patterns in HIV-1 Genes," PLOS ONE, Public Library of Science, vol. 6(12), pages 1-10, December.
    2. Anthony Mveyange & Christian Skovsgaard & Tine Lesner, 2015. "Does HIV/AIDS matter for economic growth in sub-Saharan Africa?," WIDER Working Paper Series wp-2015-086, World Institute for Development Economic Research (UNU-WIDER).
    3. Matthew Gandy, 2022. "THE ZOONOTIC CITY: Urban Political Ecology and the Pandemic Imaginary," International Journal of Urban and Regional Research, Wiley Blackwell, vol. 46(2), pages 202-219, March.
    4. Rebecca Katz & Sangeeta Mookherji & Morgan Kaminski & Vibhuti Haté & Julie E. Fischer, 2012. "Urban Governance of Disease," Administrative Sciences, MDPI, vol. 2(2), pages 1-13, April.
    5. Isiaq Oseni & Ibrahim Odusanya & Sakiru Akinbode, 2022. "Effectiveness of Foreign Aid for Health in Reducing HIV Prevalence in Sub-Saharan Africa," South-Eastern Europe Journal of Economics, Association of Economic Universities of South and Eastern Europe and the Black Sea Region, vol. 20(2), pages 141-158.
    6. Marcella M. Alsan & David M. Cutler, 2010. "Why did HIV decline in Uganda?," NBER Working Papers 16171, National Bureau of Economic Research, Inc.
    7. Robert K Bradley & Adam Roberts & Michael Smoot & Sudeep Juvekar & Jaeyoung Do & Colin Dewey & Ian Holmes & Lior Pachter, 2009. "Fast Statistical Alignment," PLOS Computational Biology, Public Library of Science, vol. 5(5), pages 1-15, May.
    8. Anthony Mveyange & Christian Skovsgaard & Tine Lesner, 2015. "Does HIV/AIDS matter for economic growth in sub-Saharan Africa?," WIDER Working Paper Series 086, World Institute for Development Economic Research (UNU-WIDER).

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