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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Author

Listed:
  • Hiroki Ishikawa

    (University of Miami School of Medicine, Miami, Florida 33136, USA)

  • Glen N. Barber

    (University of Miami School of Medicine, Miami, Florida 33136, USA)

Abstract

Interferon stung into action Hiroki Ishikawa and Glen Barber report the identification of a molecule, STING (STimulator of INterferon Genes), that recognizes DNA and RNA virus infections and activates the body's innate immune system by triggering interferon production. STING, a previously uncharacterized protein, was isolated in an expression screen for its ability to activate the interferon-β promoter. It is located mainly in the endoplasmic reticulum and promotes interferon production via activation of the IRF3 and NF-κB pathways. It also interacts with RIG-I protein, a pattern recognition receptor involved in RNA virus detection, and with the translocon adaptor Sec61β, implicating the translocon or (the translocation channel involved in translocation of nascent polypeptides into the interior (cisternal or luminal) space of the endoplasmic reticulum in innate immune signalling.

Suggested Citation

  • Hiroki Ishikawa & Glen N. Barber, 2008. "STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling," Nature, Nature, vol. 455(7213), pages 674-678, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7213:d:10.1038_nature07317
    DOI: 10.1038/nature07317
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    Cited by:

    1. Haruka Kemmoku & Kanoko Takahashi & Kojiro Mukai & Toshiki Mori & Koichiro M. Hirosawa & Fumika Kiku & Yasunori Uchida & Yoshihiko Kuchitsu & Yu Nishioka & Masaaki Sawa & Takuma Kishimoto & Kazuma Tan, 2024. "Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Alex J. Pollock & Shivam A. Zaver & Joshua J. Woodward, 2020. "A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    3. Ugur Uslu & Lijun Sun & Sofia Castelli & Amanda V. Finck & Charles-Antoine Assenmacher & Regina M. Young & Zhijian J. Chen & Carl H. June, 2024. "The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Mutian Jia & Li Chai & Jie Wang & Mengge Wang & Danhui Qin & Hui Song & Yue Fu & Chunyuan Zhao & Chengjiang Gao & Jihui Jia & Wei Zhao, 2024. "S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    5. Yongfang Lin & Jing Yang & Qili Yang & Sha Zeng & Jiayu Zhang & Yuanxiang Zhu & Yuxin Tong & Lin Li & Weiqi Tan & Dahua Chen & Qinmiao Sun, 2023. "PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    6. Tian-Chen Xiong & Ming-Cong Wei & Fang-Xu Li & Miao Shi & Hu Gan & Zhen Tang & Hong-Peng Dong & Tianzi Liuyu & Pu Gao & Bo Zhong & Zhi-Dong Zhang & Dandan Lin, 2022. "The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    7. Shirin Fatma & Arpita Chakravarti & Xuankun Zeng & Raven H. Huang, 2021. "Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    8. Mutian Jia & Yuanyuan Wang & Jie Wang & Danhui Qin & Mengge Wang & Li Chai & Yue Fu & Chunyuan Zhao & Chengjiang Gao & Jihui Jia & Wei Zhao, 2023. "Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    9. Maximilian Hirschenberger & Alice Lepelley & Ulrich Rupp & Susanne Klute & Victoria Hunszinger & Lennart Koepke & Veronika Merold & Blaise Didry-Barca & Fanny Wondany & Tim Bergner & Tatiana Moreau & , 2023. "ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    10. Martha Triantafilou & Joshi Ramanjulu & Lee M. Booty & Gisela Jimenez-Duran & Hakan Keles & Ken Saunders & Neysa Nevins & Emma Koppe & Louise K. Modis & G. Scott Pesiridis & John Bertin & Kathy Triant, 2022. "Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    11. Xiaoquan Wang & Youqiao Wang & Anqi Cao & Qinhong Luo & Daoyuan Chen & Weiqi Zhao & Jun Xu & Qinkai Li & Xianzhang Bu & Junmin Quan, 2023. "Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    12. Yaling Dou & Rui Chen & Siyao Liu & Yi-Tsang Lee & Ji Jing & Xiaoxuan Liu & Yuepeng Ke & Rui Wang & Yubin Zhou & Yun Huang, 2023. "Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    13. Rana Falahat & Anders Berglund & Patricio Perez-Villarroel & Ryan M. Putney & Imene Hamaidi & Sungjune Kim & Shari Pilon-Thomas & Glen N. Barber & James J. Mulé, 2023. "Epigenetic state determines the in vivo efficacy of STING agonist therapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    14. Xudong Chen & Min Xie & Sensen Zhang & Marta Monguió-Tortajada & Jian Yin & Chang Liu & Youqi Zhang & Maeva Delacrétaz & Mingyue Song & Yixue Wang & Lin Dong & Qiang Ding & Boda Zhou & Xiaolin Tian & , 2023. "Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    15. Jing Liu & Xia Bu & Chen Chu & Xiaoming Dai & John M. Asara & Piotr Sicinski & Gordon J. Freeman & Wenyi Wei, 2023. "PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    16. Wei-Wei Luo & Zhen Tong & Pan Cao & Fu-Bing Wang & Ying Liu & Zhou-Qin Zheng & Su-Yun Wang & Shu Li & Yan-Yi Wang, 2022. "Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    17. Matteo Gentili & Bingxu Liu & Malvina Papanastasiou & Deborah Dele-Oni & Marc A. Schwartz & Rebecca J. Carlson & Aziz M. Al’Khafaji & Karsten Krug & Adam Brown & John G. Doench & Steven A. Carr & Nir , 2023. "ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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