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A myocardial lineage derives from Tbx18 epicardial cells

Author

Listed:
  • Chen-Leng Cai

    (Skaggs School of Pharmacy,
    Department of Developmental and Regenerative Biology,
    Centre for Molecular Cardiology,
    The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, New York 10029, USA)

  • Jody C. Martin

    (Department of Bioengineering,)

  • Yunfu Sun

    (Skaggs School of Pharmacy,)

  • Li Cui

    (Skaggs School of Pharmacy,)

  • Lianchun Wang

    (Complex Carbohydrate Research Centre, University of Georgia, Athens, Georgia 30602, USA)

  • Kunfu Ouyang

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Lei Yang

    (Skaggs School of Pharmacy,)

  • Lei Bu

    (Skaggs School of Pharmacy,)

  • Xingqun Liang

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Xiaoxue Zhang

    (Skaggs School of Pharmacy,)

  • William B. Stallcup

    (Developmental Neurobiology Programme, The Burnham Institute, La Jolla, California 92037, USA)

  • Christopher P. Denton

    (Centre for Rheumatology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK)

  • Andrew McCulloch

    (Department of Bioengineering,)

  • Ju Chen

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Sylvia M. Evans

    (Skaggs School of Pharmacy,
    University of California, San Diego, La Jolla, California 92093, USA)

Abstract

Cardiac repair: New myocyte lineages Knowledge of the nature of cardiac progenitor cells is important for an understanding of the development of heart diseases, and as a potential route to regenerative therapy using stem cells. Two groups now report previously unknown cardiac myocyte lineages isolated from the proepicardium of the mouse. Cai et al. identify a population of progenitor cells that express the transcription factor Tbx18, and Zhou et al. identify cells marked by the transcription factor Wt1. Both types of progenitor are pluripotent, capable of producing several different classes of heart cell, making them promising candidates for use in cardiac repair.

Suggested Citation

  • Chen-Leng Cai & Jody C. Martin & Yunfu Sun & Li Cui & Lianchun Wang & Kunfu Ouyang & Lei Yang & Lei Bu & Xingqun Liang & Xiaoxue Zhang & William B. Stallcup & Christopher P. Denton & Andrew McCulloch , 2008. "A myocardial lineage derives from Tbx18 epicardial cells," Nature, Nature, vol. 454(7200), pages 104-108, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7200:d:10.1038_nature06969
    DOI: 10.1038/nature06969
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    Cited by:

    1. Tao Zhuang & Mei-Hua Chen & Ruo-Xi Wu & Jing Wang & Xi-De Hu & Ting Meng & Ai-Hua Wu & Yan Li & Yong-Feng Yang & Yu Lei & Dong-Hua Hu & Yan-Xiu Li & Li Zhang & Ai-Jun Sun & Wei Lu & Guan-Nan Zhang & J, 2024. "ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Emmanuel Ekow Asmah & Francis Kwaw Andoh & Edem Titriku, 2020. "Trade misinvoicing effects on tax revenue in sub‐Saharan Africa: The role of tax holidays and regulatory quality," Annals of Public and Cooperative Economics, Wiley Blackwell, vol. 91(4), pages 649-672, December.
    3. Elena Astanina & Gabriella Doronzo & Davide Corà & Francesco Neri & Salvatore Oliviero & Tullio Genova & Federico Mussano & Emanuele Middonti & Edoardo Vallariello & Chiara Cencioni & Donatella Valdem, 2022. "The TFEB-TGIF1 axis regulates EMT in mouse epicardial cells," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    4. Wei Feng & Abha Bais & Haoting He & Cassandra Rios & Shan Jiang & Juan Xu & Cindy Chang & Dennis Kostka & Guang Li, 2022. "Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    5. Mariana A. Branco & Tiago P. Dias & Joaquim M. S. Cabral & Perpetua Pinto-do-Ó & Maria Margarida Diogo, 2022. "Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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