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The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

Author

Listed:
  • Jafar Sharif

    (Tohoku University Biomedical Engineering Research Organization (TUBERO), 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
    Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
    Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan)

  • Masahiro Muto

    (RIKEN Research Center for Allergy and Immunology,)

  • Shin-ichiro Takebayashi

    (RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan)

  • Isao Suetake

    (Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Akihiro Iwamatsu

    (Protein-Research Network, Inc., 1-13-5 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan)

  • Takaho A. Endo

    (RIKEN Genomic Sciences Center, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan)

  • Jun Shinga

    (RIKEN Research Center for Allergy and Immunology,)

  • Yoko Mizutani-Koseki

    (RIKEN Research Center for Allergy and Immunology,)

  • Tetsuro Toyoda

    (RIKEN Genomic Sciences Center, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan)

  • Kunihiro Okamura

    (Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan)

  • Shoji Tajima

    (Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Kohzoh Mitsuya

    (Tohoku University Biomedical Engineering Research Organization (TUBERO), 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan)

  • Masaki Okano

    (RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan)

  • Haruhiko Koseki

    (RIKEN Research Center for Allergy and Immunology,)

Abstract

Np95 recruits the DNA methyltransferase Dnmt1 to hemi-methylated DNA at replicating heterochromatic regions. It is required in vivo to maintain DNA methylation and repress transcription of retrotransposons and imprinted genes

Suggested Citation

  • Jafar Sharif & Masahiro Muto & Shin-ichiro Takebayashi & Isao Suetake & Akihiro Iwamatsu & Takaho A. Endo & Jun Shinga & Yoko Mizutani-Koseki & Tetsuro Toyoda & Kunihiro Okamura & Shoji Tajima & Kohzo, 2007. "The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA," Nature, Nature, vol. 450(7171), pages 908-912, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7171:d:10.1038_nature06397
    DOI: 10.1038/nature06397
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    Citations

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    Cited by:

    1. Kosuke Yamaguchi & Xiaoying Chen & Brianna Rodgers & Fumihito Miura & Pavel Bashtrykov & Frédéric Bonhomme & Catalina Salinas-Luypaert & Deis Haxholli & Nicole Gutekunst & Bihter Özdemir Aygenli & Lau, 2024. "Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Amika Kikuchi & Hiroki Onoda & Kosuke Yamaguchi & Satomi Kori & Shun Matsuzawa & Yoshie Chiba & Shota Tanimoto & Sae Yoshimi & Hiroki Sato & Atsushi Yamagata & Mikako Shirouzu & Naruhiko Adachi & Jafa, 2022. "Structural basis for activation of DNMT1," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. María Arroyo & Florian D. Hastert & Andreas Zhadan & Florian Schelter & Susanne Zimbelmann & Cathia Rausch & Anne K. Ludwig & Thomas Carell & M. Cristina Cardoso, 2022. "Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation," Nature Communications, Nature, vol. 13(1), pages 1-28, December.
    4. Lianmei Tan & Tao Yin & Handan Xiang & Liuyang Wang & Poorva Mudgal & Junying Chen & Yi Ding & Guoping Wang & Bryan Jian Wei Lim & Yuqi Huang & De Huang & Yaosi Liang & Peter B. Alexander & Kun Xiang , 2024. "Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    5. Jiajun Tan & Yingfeng Li & Xiang Li & Xiaoxiao Zhu & Liping Liu & Hua Huang & Jiahua Wei & Hailing Wang & Yong Tian & Zhigao Wang & Zhuqiang Zhang & Bing Zhu, 2024. "Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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