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Structural basis of Dscam isoform specificity

Author

Listed:
  • Rob Meijers

    (Department of Medical Oncology and,
    Department of Medicine,
    Present address: Synchrotron Soleil, L’Orme des Merisiers, 91192 Saint Aubin, France.)

  • Roland Puettmann-Holgado

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Department of Neurobiology,
    Institute for Biology III, University of Freiburg)

  • Georgios Skiniotis

    (Department of Cell Biology,)

  • Jin-huan Liu

    (Department of Medical Oncology and,
    Department of Medicine,)

  • Thomas Walz

    (Department of Cell Biology,)

  • Jia-huai Wang

    (Department of Medical Oncology and,
    Department of Pediatrics and,
    Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Dietmar Schmucker

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Department of Neurobiology,)

Abstract

Crystal structures of the amino-terminal four immunoglobulin domains of two Dscam isoforms, coupled with biochemical analysis, reveals a horseshoe-shaped configuration and an epitope that confers homophilic dimerization specificity of Dscam receptors.

Suggested Citation

  • Rob Meijers & Roland Puettmann-Holgado & Georgios Skiniotis & Jin-huan Liu & Thomas Walz & Jia-huai Wang & Dietmar Schmucker, 2007. "Structural basis of Dscam isoform specificity," Nature, Nature, vol. 449(7161), pages 487-491, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7161:d:10.1038_nature06147
    DOI: 10.1038/nature06147
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    Cited by:

    1. Jie Cheng & Yamei Yu & Xingyu Wang & Xi Zheng & Ting Liu & Daojun Hu & Yongfeng Jin & Ying Lai & Tian-Min Fu & Qiang Chen, 2023. "Structural basis for the self-recognition of sDSCAM in Chelicerata," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Christos Gogou & J. Wouter Beugelink & Cátia P. Frias & Leanid Kresik & Natalia Jaroszynska & Uwe Drescher & Bert J. C. Janssen & Robert Hindges & Dimphna H. Meijer, 2024. "Alternative splicing controls teneurin-3 compact dimer formation for neuronal recognition," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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