IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v449y2007i7161d10.1038_nature06147.html
   My bibliography  Save this article

Structural basis of Dscam isoform specificity

Author

Listed:
  • Rob Meijers

    (Department of Medical Oncology and,
    Department of Medicine,
    Present address: Synchrotron Soleil, L’Orme des Merisiers, 91192 Saint Aubin, France.)

  • Roland Puettmann-Holgado

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Department of Neurobiology,
    Institute for Biology III, University of Freiburg)

  • Georgios Skiniotis

    (Department of Cell Biology,)

  • Jin-huan Liu

    (Department of Medical Oncology and,
    Department of Medicine,)

  • Thomas Walz

    (Department of Cell Biology,)

  • Jia-huai Wang

    (Department of Medical Oncology and,
    Department of Pediatrics and,
    Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Dietmar Schmucker

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Department of Neurobiology,)

Abstract

Crystal structures of the amino-terminal four immunoglobulin domains of two Dscam isoforms, coupled with biochemical analysis, reveals a horseshoe-shaped configuration and an epitope that confers homophilic dimerization specificity of Dscam receptors.

Suggested Citation

  • Rob Meijers & Roland Puettmann-Holgado & Georgios Skiniotis & Jin-huan Liu & Thomas Walz & Jia-huai Wang & Dietmar Schmucker, 2007. "Structural basis of Dscam isoform specificity," Nature, Nature, vol. 449(7161), pages 487-491, September.
  • Handle: RePEc:nat:nature:v:449:y:2007:i:7161:d:10.1038_nature06147
    DOI: 10.1038/nature06147
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06147
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature06147?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jie Cheng & Yamei Yu & Xingyu Wang & Xi Zheng & Ting Liu & Daojun Hu & Yongfeng Jin & Ying Lai & Tian-Min Fu & Qiang Chen, 2023. "Structural basis for the self-recognition of sDSCAM in Chelicerata," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Christos Gogou & J. Wouter Beugelink & Cátia P. Frias & Leanid Kresik & Natalia Jaroszynska & Uwe Drescher & Bert J. C. Janssen & Robert Hindges & Dimphna H. Meijer, 2024. "Alternative splicing controls teneurin-3 compact dimer formation for neuronal recognition," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:449:y:2007:i:7161:d:10.1038_nature06147. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.