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JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling

Author

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  • Bryan Thines

    (Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA
    Present address: USDA Plant Gene Expression Center, 800 Buchanan Street, Albany, California 94710, USA.)

  • Leron Katsir

    (Department of Energy-Plant Research Laboratory,
    Department of Biochemistry and Molecular Biology,)

  • Maeli Melotto

    (Department of Energy-Plant Research Laboratory,)

  • Yajie Niu

    (Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA)

  • Ajin Mandaokar

    (Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA)

  • Guanghui Liu

    (Department of Energy-Plant Research Laboratory,)

  • Kinya Nomura

    (Department of Energy-Plant Research Laboratory,)

  • Sheng Yang He

    (Department of Energy-Plant Research Laboratory,
    Michigan State University, East Lansing, Michigan 48824, USA)

  • Gregg A. Howe

    (Department of Energy-Plant Research Laboratory,
    Department of Biochemistry and Molecular Biology,)

  • John Browse

    (Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA)

Abstract

Jasmonate and related signalling compounds have a crucial role in both host immunity and development in plants, but the molecular details of the signalling mechanism are poorly understood. Here we identify members of the jasmonate ZIM-domain (JAZ) protein family as key regulators of jasmonate signalling. JAZ1 protein acts to repress transcription of jasmonate-responsive genes. Jasmonate treatment causes JAZ1 degradation and this degradation is dependent on activities of the SCFCOI1 ubiquitin ligase and the 26S proteasome. Furthermore, the jasmonoyl–isoleucine (JA–Ile) conjugate, but not other jasmonate-derivatives such as jasmonate, 12-oxo-phytodienoic acid, or methyl-jasmonate, promotes physical interaction between COI1 and JAZ1 proteins in the absence of other plant proteins. Our results suggest a model in which jasmonate ligands promote the binding of the SCFCOI1 ubiquitin ligase to and subsequent degradation of the JAZ1 repressor protein, and implicate the SCFCOI1–JAZ1 protein complex as a site of perception of the plant hormone JA–Ile.

Suggested Citation

  • Bryan Thines & Leron Katsir & Maeli Melotto & Yajie Niu & Ajin Mandaokar & Guanghui Liu & Kinya Nomura & Sheng Yang He & Gregg A. Howe & John Browse, 2007. "JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling," Nature, Nature, vol. 448(7154), pages 661-665, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7154:d:10.1038_nature05960
    DOI: 10.1038/nature05960
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    Cited by:

    1. Yao Xia & Rongfeng Zou & Maxime Escouboué & Liang Zhong & Chengjun Zhu & Cécile Pouzet & Xueqiang Wu & Yongjin Wang & Guohua Lv & Haibo Zhou & Pinghua Sun & Ke Ding & Laurent Deslandes & Shuguang Yuan, 2021. "Secondary-structure switch regulates the substrate binding of a YopJ family acetyltransferase," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    2. Xiaoyue Chen & Graham A. Hudson & Charlotte Mineo & Bashar Amer & Edward E. K. Baidoo & Samantha A. Crowe & Yuzhong Liu & Jay D. Keasling & Henrik V. Scheller, 2023. "Deciphering triterpenoid saponin biosynthesis by leveraging transcriptome response to methyl jasmonate elicitation in Saponaria vaccaria," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Ameneh Asadi-Sardari & Esmat Mahdikhani-Moghadam & Mohammad Zaki-Aghl & Ramesh Raju Vetukuri, 2022. "Constitutive and Inducible Expression of Genes Related to Salicylic Acid and Ethylene Pathways in a Moderately Resistant Tomato Cultivar Leads to Delayed Development of Meloidogyne javanica," Agriculture, MDPI, vol. 12(12), pages 1-22, December.
    4. Zi-Wei Yan & Fang-Yan Chen & Xian Zhang & Wen-Juan Cai & Chun-Yu Chen & Jie Liu & Man-Ni Wu & Ning-Jing Liu & Bin Ma & Mu-Yang Wang & Dai-Yin Chao & Cai-Ji Gao & Ying-Bo Mao, 2023. "Endocytosis-mediated entry of a caterpillar effector into plants is countered by Jasmonate," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Jinping Zou & Xinlin Chen & Chenxu Liu & Mingyue Guo & Mukesh Kumar Kanwar & Zhenyu Qi & Ping Yang & Guanghui Wang & Yan Bao & Diane C. Bassham & Jingquan Yu & Jie Zhou, 2023. "Autophagy promotes jasmonate-mediated defense against nematodes," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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