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Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Author

Listed:
  • Miriam F. Moffatt

    (National Heart and Lung Institute, Imperial College, London SW3 6LY, UK)

  • Michael Kabesch

    (University Children's Hospital, Ludwig Maximilians University, D80337 Munich, Germany)

  • Liming Liang

    (Center for Statistical Genetics, SPH II, Ann Arbor, Michigan 48109-2029, USA)

  • Anna L. Dixon

    (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK)

  • David Strachan

    (St George's, University of London, London SW17 0RE, UK)

  • Simon Heath

    (Centre National de Génotypage, Institut Génomique, Commissariat à l'Énergie Atomique, 91057 Evry, France)

  • Martin Depner

    (University Children's Hospital, Ludwig Maximilians University, D80337 Munich, Germany)

  • Andrea von Berg

    (Research Institute for the Prevention of Allergic Diseases, Marien-Hospital, D46483 Wesel, Germany)

  • Albrecht Bufe

    (Ruhr-University, D44789 Bochum, Germany)

  • Ernst Rietschel

    (University Children's Hospital, University of Cologne, D50924 Cologne, Germany)

  • Andrea Heinzmann

    (University Children's Hospital, Albert Ludwigs University, D79106 Freiburg, Germany)

  • Burkard Simma

    (Feldkirch Hospital, A6800 Feldkirch, Austria)

  • Thomas Frischer

    (University Children's Hospital Vienna, A1090 Vienna, Austria)

  • Saffron A. G. Willis-Owen

    (National Heart and Lung Institute, Imperial College, London SW3 6LY, UK)

  • Kenny C. C. Wong

    (National Heart and Lung Institute, Imperial College, London SW3 6LY, UK)

  • Thomas Illig

    (Institute of Epidemiology, GSF-Research Centre for Environment and Health, D85764 Neuherberg, Germany)

  • Christian Vogelberg

    (University Children's Hospital, Technical University Dresden, D01307 Dresden, Germany)

  • Stephan K. Weiland

    (Institute of Epidemiology, Ulm University, D89081 Germany)

  • Erika von Mutius

    (University Children's Hospital, Ludwig Maximilians University, D80337 Munich, Germany)

  • Gonçalo R. Abecasis

    (Center for Statistical Genetics, SPH II, Ann Arbor, Michigan 48109-2029, USA)

  • Martin Farrall

    (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK)

  • Ivo G. Gut

    (Centre National de Génotypage, Institut Génomique, Commissariat à l'Énergie Atomique, 91057 Evry, France)

  • G. Mark Lathrop

    (Centre National de Génotypage, Institut Génomique, Commissariat à l'Énergie Atomique, 91057 Evry, France)

  • William O. C. Cookson

    (National Heart and Lung Institute, Imperial College, London SW3 6LY, UK)

Abstract

Childhood asthma genes Rates of childhood asthma diagnosis are rising: 6% of children in the United States are sufferers. Both genetic and environmental factors are clearly important. To discover more about the genetic element, Moffatt et al. looked for genes linked to asthma in a genome-wide association scan. More than a third of children with asthma of onset below the age of seven showed variations in expression of the ORMDL3 gene on chromosome 17. Similar genes are found in yeast and other primitive organisms, suggesting that they may be components of an ancient and conserved immune mechanism.

Suggested Citation

  • Miriam F. Moffatt & Michael Kabesch & Liming Liang & Anna L. Dixon & David Strachan & Simon Heath & Martin Depner & Andrea von Berg & Albrecht Bufe & Ernst Rietschel & Andrea Heinzmann & Burkard Simma, 2007. "Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma," Nature, Nature, vol. 448(7152), pages 470-473, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7152:d:10.1038_nature06014
    DOI: 10.1038/nature06014
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    Cited by:

    1. Thorunn A. Olafsdottir & Gudmar Thorleifsson & Aitzkoa Lopez de Lapuente Portilla & Stefan Jonsson & Lilja Stefansdottir & Abhishek Niroula & Aslaug Jonasdottir & Hannes P. Eggertsson & Gisli H. Halld, 2024. "Sequence variants influencing the regulation of serum IgG subclass levels," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Jin Hyun Ju & Sushila A Shenoy & Ronald G Crystal & Jason G Mezey, 2017. "An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci," PLOS Computational Biology, Public Library of Science, vol. 13(5), pages 1-26, May.
    3. Josine L Min & Jennifer M Taylor & J Brent Richards & Tim Watts & Fredrik H Pettersson & John Broxholme & Kourosh R Ahmadi & Gabriela L Surdulescu & Ernesto Lowy & Christian Gieger & Chris Newton-Cheh, 2011. "The Use of Genome-Wide eQTL Associations in Lymphoblastoid Cell Lines to Identify Novel Genetic Pathways Involved in Complex Traits," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-14, July.
    4. Michael A Nalls & David J Couper & Toshiko Tanaka & Frank J A van Rooij & Ming-Huei Chen & Albert V Smith & Daniela Toniolo & Neil A Zakai & Qiong Yang & Andreas Greinacher & Andrew R Wood & Melissa G, 2011. "Multiple Loci Are Associated with White Blood Cell Phenotypes," PLOS Genetics, Public Library of Science, vol. 7(6), pages 1-16, June.
    5. Lina-Marcela Diaz-Gallo & Elena Sánchez & Norberto Ortego-Centeno & Jose Mario Sabio & Francisco J García-Hernández & Enrique de Ramón & Miguel A González-Gay & Torsten Witte & Hans-Joachim Anders & M, 2013. "Evidence of New Risk Genetic Factor to Systemic Lupus Erythematosus: The UBASH3A Gene," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-5, April.
    6. Tian Xie & Peng Liu & Xinyue Wu & Feitong Dong & Zike Zhang & Jian Yue & Usha Mahawar & Faheem Farooq & Hisham Vohra & Qi Fang & Wenchen Liu & Binks W. Wattenberg & Xin Gong, 2023. "Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    7. Hang Yin & Jian Zheng & Qiuqiu He & Xuan Zhang & Xuzichao Li & Yongjian Ma & Xiao Liang & Jiaqi Gao & Benjamin L. Kocsis & Zhuang Li & Xiang Liu & Neal M. Alto & Long Li & Heng Zhang, 2023. "Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    8. Guangdie Yang & Junjun Chen & Fei Xu & Zhang Bao & Yake Yao & Jianying Zhou, 2014. "Association between Tumor Necrosis Factor-α rs1800629 Polymorphism and Risk of Asthma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-11, June.
    9. Ya Cui & Frederick J. Arnold & Fanglue Peng & Dan Wang & Jason Sheng Li & Sebastian Michels & Eric J. Wagner & Albert R. Spada & Wei Li, 2023. "Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    10. Joverlyn Gaudillo & Jae Joseph Russell Rodriguez & Allen Nazareno & Lei Rigi Baltazar & Julianne Vilela & Rommel Bulalacao & Mario Domingo & Jason Albia, 2019. "Machine learning approach to single nucleotide polymorphism-based asthma prediction," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-12, December.
    11. Leyao Wang & William Murk & Andrew T DeWan, 2015. "Genome-Wide Gene by Environment Interaction Analysis Identifies Common SNPs at 17q21.2 that Are Associated with Increased Body Mass Index Only among Asthmatics," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-14, December.
    12. Adaikalavan Ramasamy & Mikko Kuokkanen & Sailaja Vedantam & Zofia K Gajdos & Alexessander Couto Alves & Helen N Lyon & Manuel A R Ferreira & David P Strachan & Jing Hua Zhao & Michael J Abramson & Mat, 2012. "Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-10, September.
    13. Ryan Abo & Gregory D Jenkins & Liewei Wang & Brooke L Fridley, 2012. "Identifying the Genetic Variation of Gene Expression Using Gene Sets: Application of Novel Gene Set eQTL Approach to PharmGKB and KEGG," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-11, August.

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